David M. Weinstein

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Diffusion tensor MRI provides unique directional diffusion information that can be used to estimate the patterns of white matter connectivity in the human brain. In this study, the behavior of an algorithm for white matter tractography is examined. The algorithm, called TEND, uses the entire diffusion tensor to deflect the estimated fiber trajectory.(More)
Tracking linear features through tensor field datasets is an open research problem with widespread utility in medical and engineering disciplines. Existing tracking methods, which consider only the preferred local diffusion direction as they propagate, fail to accurately follow features as they enter regions of local complexity. This shortcoming is a result(More)
In recent years, significant progress has been made in the area of electroencephalography (EEG) source imaging. Source localization on simple spherical models has become increasingly efficient, with consistently reported accuracy of within 5 mm. In contrast, source localization on realistic head models remains slow, with subcentimeter accuracy being the(More)
ÐDiffusion-weighted magnetic resonance imaging is a relatively new modality capable of elucidating the fibrous structure of certain types of tissue, such as the white matter within the brain. One tool for interpreting this data is volume rendering because it permits the visualization of three dimensional structure without a prior segmentation process. In(More)
With the development of magnetic resonance imaging techniques for acquiring diffusion tensor data from biological tissue, visualization of tensor data has become a new research focus. The diffusion tensor describes the directional dependence of water molecules' diffusion and can be represented by a three-by-three symmetric matrix. Visualization of(More)
In this paper we describe applications of the SCIRun system to large-scale computational science problems. SCIRun is a scientific problem solving environment that allows the interactive construction and steering of large-scale scientific computations. A scientific application is constructed by connecting computational elements (modules) to form a program(More)
Event-related potentials (ERPs) provide a noninvasive method to evaluate neural activation and cognitive processes in schizophrenia. The pathophysiological significance of these findings would be greatly enhanced if scalp-recorded ERP abnormalities could be related to specific neural circuits and/or regions of the brain. Using quantitative approaches in(More)
Cardiac peroxynitrite and protein nitration are increased during doxorubicin cardiotoxicity, but the intracellular targets and functional consequences have not been defined. We investigated the intracellular distribution of protein nitration during doxorubicin cardiotoxicity in mice. Following in vivo cardiac function assessments by echocardiography,(More)
Seventeen patients who had osteoarthritis of the glenohumeral joint after surgery for glenohumeral instability underwent prosthetic replacement. Thirteen men and four women with an average age of 43 years were studied. The interval from the initial instability repair to prosthetic replacement averaged 16 years. Before the operation all patients had severe(More)