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The Alzheimer's disease beta-amyloid peptide (Abeta) is produced by excision from the type 1 integral membrane glycoprotein amyloid precursor protein (APP) by the sequential actions of beta- and then gamma-secretases. Here we report that Asp 2, a novel transmembrane aspartic protease, has the key activities expected of beta-secretase. Transient expression(More)
Sequential proteolytic processing of the Amyloid Precursor Protein (APP) by beta- and gamma-secretases generates the 4-kDa amyloid (A beta) peptide, a key component of the amyloid plaques seen in Alzheimer's disease (AD). We and others have recently reported the identification and characterisation of an aspartic proteinase, Asp2 (BACE), as beta-secretase.(More)
This paper describes the development and implementation of an optimization model used to resolve disruptions to an operating schedule in the rail industry. Alterations to the existing train timetable and crewing roster are made simultaneously in real time—previous treatments in the literature have always decoupled these two problems and solved them in(More)
The need to recover a train driver schedule occurs during major disruptions in the daily railway operations. Using data from the train driver schedule of the Dan-ish passenger railway operator DSB S-tog A/S, a solution method to the Train Driver Recovery Problem (TDRP) is developed. The TDRP is formulated as a set partitioning problem. The LP relaxation of(More)
Benders' decomposition is a well-known technique for solving large linear programs with a special structure. In particular it is a popular technique for solving multi-stage stochastic linear programming problems. Early termination in the subproblems generated during Benders' decomposition (assuming dual feasibility) produces valid cuts which are inexact in(More)