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The Alzheimer's disease beta-amyloid peptide (Abeta) is produced by excision from the type 1 integral membrane glycoprotein amyloid precursor protein (APP) by the sequential actions of beta- and then gamma-secretases. Here we report that Asp 2, a novel transmembrane aspartic protease, has the key activities expected of beta-secretase. Transient expression(More)
The need to recover a train driver schedule occurs during major disruptions in the daily railway operations. Using data from the train driver schedule of the Dan-ish passenger railway operator DSB S-tog A/S, a solution method to the Train Driver Recovery Problem (TDRP) is developed. The TDRP is formulated as a set partitioning problem. The LP relaxation of(More)
Forest Harvest Scheduling problems incorporating area-based restrictions have been of great practical interest for several years, but only recently have advances been made that allow them to be efficiently solved. One significant development has made use of formulation strengthening using the Cluster Packing Problem. This improved formulation has allowed(More)
Sequential proteolytic processing of the Amyloid Precursor Protein (APP) by beta- and gamma-secretases generates the 4-kDa amyloid (A beta) peptide, a key component of the amyloid plaques seen in Alzheimer's disease (AD). We and others have recently reported the identification and characterisation of an aspartic proteinase, Asp2 (BACE), as beta-secretase.(More)
The role of the herpes simplex virus (HSV)-encoded ribonucleotide reductase (RR) in the pathogenicity of the virus has been examined by use of mutants with lesions in either the large or small subunit of the enzyme. The virulence of the mutants in mice was reduced by about 10(6)-fold when compared with that of the parental virus (HSV type 1 strain 17),(More)
This paper describes the development and implementation of an optimization model used to resolve disruptions to an operating schedule in the rail industry. Alterations to the existing train timetable and crewing roster are made simultaneously in real time—previous treatments in the literature have always decoupled these two problems and solved them in(More)