David M. Rosenberg

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Neural circuits implicated in drug conditioning, craving and relapse overlap extensively with those involved in natural reward and reinforcement. To determine whether specificity could be detected in conditioned brain responses to drugs versus food, male outbred HSD:ICR mice were conditioned to a common environment using either 20 mg/kg cocaine (ip) or a(More)
The problem of assessing pollution in the catchment of the Fraser River, British Columbia, Canada, was addressed by using benthic macroinvertebrates to develop a biomonitoring program based on the reference-condition approach to water-quality assessment. The reference condition is represented by groups of minimally disturbed sites organized by selected(More)
Outbred laboratory mouse populations are widely used in biomedical research. Since little is known about the degree of genetic variation present in these populations, they are not widely used for genetic studies. Commercially available outbred CD-1 mice are drawn from an extremely large breeding population that has accumulated many recombination events,(More)
Reference-condition models for the Fraser River catchment were developed using samples collected during The goal of this study was to examine applicability to the reference-condition models of samples collected in other seasons and the effect of taxonomic resolution (genus and family) on model sensitivity to seasonal variation in the benthic invertebrate(More)
Benthic (bottom-dwelling) macroinvertebrates are the basis for most biomonitoring programs currently in operation worldwide (Rosenberg and Resh 1993), and the reasons underlying the use of these organisms are compelling (Rosenberg and Resh 1996). In the United States, regional programs tend to be local modifications of national programs (e.g. Plafkin et al.(More)
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