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Axonal degeneration is a major cause of permanent disability in multiple sclerosis (MS). Recent observations from our and other laboratories suggest that sodium accumulation within compromised axons is a key, early step in the degenerative process, and hence that limiting axonal sodium influx may represent a mechanism for axonal protection in MS. Here we(More)
The present study reports that it is possible to induce kindling by repeated injections of nicotine. The newly characterised nicotine-kindling model was compared with that of pentylenetetrazole (PTZ) kindling. Mice were kindled by repeated injection of PTZ (37 mg/kg), or nicotine (2.3 mg/kg), and the effect of the anti-epileptic drugs (AED) levetiracetam(More)
This paper examines some of the ethical problems involved in undertaking Internet research and draws on historical accounts as well as contemporary studies to offer an analysis of the issues raised. It argues that privacy is a misleading and confusing concept to apply to the Internet, and that the concept of non-alienation is more resourceful in addressing(More)
A preliminary investigation into the discourse of the free/libre and open source movements This paper uses discourse analysis to examine the free/libre and open source movements. It analyses how they fix elements within the order of discourse of computer code production. It attempts to uncover the key signifiers in their discourses and trace linkages(More)
Antiepileptic and antipsychotic drugs are often prescribed together. Interactions between the drugs may affect both efficacy and toxicity. This is a review of human clinical data on the interactions between the antiepileptic drugs carbamazepine, valproic acid (sodium valproate), vigabatrin, lamotrigine, gabapentin, topiramate, tiagabine, oxcarbazepine,(More)
Recognized as great works of world literature, Shakespeare's poems and plays have been translated into dozens of languages for over 300 years. Also, there are many re-translations into the same language, for example, there are more than 60 translations of Othello into German. Every translation is a different interpretation of the play. These large(More)