David Lutje Hulsik | Semantic Scholar

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Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane.

Gilles Bodon, Romain Chassefeyre, +10 authors Rémy Sadoul
The Journal of biological chemistry
2011

The endosomal sorting complexes required for transport (ESCRT-0-III) allow membrane budding and fission away from the cytosol. This machinery is used during multivesicular endosome biogenesis,… (More)

Structural basis for ESCRT-III CHMP3 recruitment of AMSH.

Julianna Solomons, Charles Sabin, +6 authors Winfried Weissenhorn
Structure
2011

Endosomal sorting complexes required for transport (ESCRT) recognize ubiquitinated cargo and catalyze diverse budding processes including multivesicular body biogenesis, enveloped virus egress, and… (More)

Llama Antibody Fragments Recognizing Various Epitopes of the CD4bs Neutralize a Broad Range of HIV-1 Subtypes A, B and C

Nika M. Strokappe, Agnieszka Szynol, +7 authors Theo Verrips
PloS one
2012

Many of the neutralising antibodies, isolated to date, display limited activities against the globally most prevalent HIV-1 subtypes A and C. Therefore, those subtypes are considered to be an… (More)

Modelling G protein-coupled receptors

Luís Oliveira, Tim Hulsen, David Lutje Hulsik, Antonio C. M. Paiva, Gert Vriend
2002

Antibody engineering reveals the important role of J segments in the production efficiency of llama single-domain antibodies in Saccharomyces cerevisiae.

Andrea Gorlani, David Lutje Hulsik, Henry Adams, Gerrit Vriend, P.M.J.A. Hermans, Theo C Verrips
Protein engineering, design & selection : PEDS
2012

Variable domains of llama heavy-chain antibodies (VHH) are becoming a potent tool for a wide range of biotechnological and medical applications. Because of structural features typical of their… (More)

A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1.

Rachel Pei-Jen Lai, Miriam Hock, +15 authors Winfried Weissenhorn
The Journal of biological chemistry
2014

The membrane-proximal external region (MPER) of the human immunodeficiency virus, type 1 (HIV-1) envelope glycoprotein subunit gp41 is targeted by potent broadly neutralizing antibodies 2F5, 4E10,… (More)

Crystal Structure and Size-Dependent Neutralization Properties of HK 20 , a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp 41

Charles Sabin, Davide Corti, +12 authors Winfried Weissenhorn
2010

The human monoclonal antibody (mAb) HK20 neutralizes a broad spectrum of primary HIV-1 isolates by targeting the highly conserved heptad repeat 1 (HR1) of gp41, which is transiently exposed during… (More)

Improving properties of llama heavy chain antibodies using in silico analysis

David Lutje Hulsik
2009

Microbicides offer a promising way to prevent HIV infection in developing countries. Llama heavy chain antibody fragments (VHHs) that neutralize HIV are an ideal candidate for usage as active… (More)

Abstract 2645: Development of a first in class APRIL fully blocking antibody BION-1301 for the treatment of multiple myeloma

John Dulos, Lilian Driessen, +9 authors Andrea van Elsas
2017

Abstract 1246: Development of an agonistic antibody against the human T-cell costimulatory receptor CD27 as a potential immunotherapeutic tool.

Hans van Eenennaam, Elise A. M. Veraar, +8 authors Andrea van Elsas
2013

Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Immunotherapy of cancer has reached a mature and exciting stage. Clinical activity of monoclonal antibodies (mAb) against… (More)