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Information retrieval (IR) systems are responsible for the storage and retrieval of large amounts of data in an efficient manner. An important subtask of IR is searching, which deals with retrieving documents stored within the system in response to a user's information needs. Many IR systems deal with text documents, and a myriad of techniques has been(More)
The roles of 3',5'-cyclic adenosine monophosphate (cAMP) and protein kinase A in 5-hydroxytryptamine (5-HT)7 receptor-mediated activation of extracellular-regulated kinase (ERK) were studied in cultured hippocampal neurons and transfected PC12 cells. Activation of ERK by neuronal Gs-coupled receptors has been thought to proceed through a protein kinase(More)
Several studies conducted in diverse fields indicate the presence of a genetic discontinuity within the taxon Galago crassicaudatus E. Geoffroy--the thick-tailed bushbaby. One of these areas is morphology. This contribution details a statistical analysis of skull material classified under this taxon in order 1) to confirm the objective existence of two(More)
Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with corresponding sequences from the bradykinin B2 receptor (BKB2R). The hybrids(More)
The role of the first intracellular loop (IC1) in the function of the rat bradykinin B2 receptor (BKB2R) was probed. On the basis of the bovine rhodopsin X-ray structure, the BKB2R IC1 consists of six residues: (60)HKTNCT. Exchange of this sequence with the bradykinin B1 receptor IC1 (PRRQLN) resulted in a chimera which bound bradykinin and signaled as(More)
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