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In the life sciences, many measurement methods yield only the relative abundances of different components in a sample. With such relative-or compositional-data, differential expression needs careful interpretation, and correlation-a statistical workhorse for analyzing pairwise relationships-is an inappropriate measure of association. Using yeast gene(More)
When crystallization screening is conducted many outcomes are observed but typically the only trial recorded in the literature is the condition that yielded the crystal(s) used for subsequent diffraction studies. The initial hit that was optimized and the results of all the other trials are lost. These missing results contain information that would be(More)
Changes in technology, economy and society create challenges that force us to rethink the way we develop systems. Model-Based Systems Engineering is an approach that can prove catalytic in this new era of systems development. In this work we introduce the concept of the modeling " hub " in order to realize the vision of Model-Based Systems Engineering and(More)
Many techniques in information retrieval produce counts from a sample, and it is common to analyse these counts as proportions of the whole---term frequencies are a familiar example. Proportions carry only relative information and are not free to vary independently of one another: for the proportion of one term to increase, one or more others must decrease.(More)
1. ensure the research reported in Proportionality: a valid alternative to correlation for relative data is reproducible. This document was produced in RStudio using Sweave [1] and the knitr package [2] from the file SupplementaryInfo.Rnw available in the Supplementary Information zip file. 2. provide additional detail, figures and information for those(More)
Circular shortest paths represent a powerful methodology for image segmentation. The circularity condition ensures that the contour found by the algorithm is closed, a natural requirement for regular objects. Several implementations have been proposed in the past that either promise closure with high probability or ensure closure strictly, but with a mild(More)
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