David London

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We have conducted experiments on dissolution of quartz, albite, orthoclase, and corundum into H2O-saturated haplogranite melt at 800 C and 200MPa over a duration of 120–1488 h with the aim of ascertaining the diffusive transport properties of granitic melts at crustal anatectic temperatures. Cylinders of anhydrous starting glass and a single mineral phase(More)
We consider within the standard model the time-dependent decay rates of the three processes B °--,D°Ks, D°Ks and Dr°Ks, where D O is a neutral D meson CP-eigenstate. We show that it is possible to derive from these processes, in which two weak amplitudes are involved, two of the three angles in the unitarity triangle of the Cabibbo-Kobayashi-Maskawa matrix.(More)
Yellow-brown to pink Mn-rich tourmalines with MnO contents in the range 8–9 wt% MnO (~0.1 wt% FeO) from a recently discovered locality in Austria, near Eibenstein an der Thaya (Lower Austria), have been characterized by crystal structure determination, by chemical analyses (EMPA, SIMS), and by optical absorption spectroscopy. Qualitatively, the optical(More)
Androgens have important physiological effects in women. Not only are they the precursor hormones for estrogen biosynthesis in the ovaries and extragonadal tissues, but also act directly via androgen receptors (ARs) throughout the body. Studies of the role of androgens on breast cancer development are controversial and the mechanisms involved are not fully(More)
Transactional sex may put young women and young men in sub-Saharan Africa at increased risk of contracting sexually transmitted infections (STIs), including HIV/AIDS. This behavior may also put young women at higher risk of pregnancy and childbearing. Policymakers and program managers need to know what factors put youth at increased risk. We investigated(More)
Thyroid hormone induces tumor cell and blood vessel cell proliferation via a cell surface receptor on heterodimeric integrin αvβ3. We investigated the role of thyroid hormone-induced internalization of nuclear integrin αv monomer. Physiological concentration of thyroxine (free T4, 10(-10) M), but not 3,5,3'-triiodo-l-thyronine (T3), induced cellular(More)
A cell surface receptor for thyroid hormone that activates extracellular regulated kinase (ERK) 1/2 has been identified on integrin αvβ3. We have examined the actions of thyroid hormone initiated at the integrin on human NCI-H522 non-small cell lung carcinoma and NCI-H510A small cell lung cancer cells. At a physiologic total hormone concentration (10(-7)(More)
Unmodified or as a poly[lactide-co-glycolide] nanoparticle, tetraiodothyroacetic acid (tetrac) acts at the integrin αvβ3 receptor on human cancer cells to inhibit tumor cell proliferation and xenograft growth. To study in vitro the pharmacodynamics of tetrac formulations in the absence of and in conjunction with other chemotherapeutic agents, we developed a(More)
We have used a perfusion bellows cell culture system to investigate resveratrolinduced anti-proliferation/apoptosis in a human estrogen receptor (ER)-negative breast cancer cell line (MDA-MB-231). Using an injection system to perfuse media with stilbene, we showed resveratrol (0.5 - 100 μM) to decrease cell proliferation in a concentration-dependent manner.(More)