David Lodge

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Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.

Tage Honoré, Stephen N. Davies, +4 authors Finn Erland Nielsen
Science
1988

The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate… (More)

Kainate receptors are involved in synaptic plasticity

Zuner Assis Bortolotto, Vernon R. J. Clarke, +13 authors Graham L Collingridge
Nature
1999

The ability of synapses to modify their synaptic strength in response to activity is a fundamental property of the nervous system and may be an essential component of learning and memory. There are… (More)

A Critical Role of a Facilitatory Presynaptic Kainate Receptor in Mossy Fiber LTP

Sari E Lauri, Zuner Assis Bortolotto, +4 authors Graham L Collingridge
Neuron
2001

The mechanisms involved in mossy fiber LTP in the hippocampus are not well established. In the present study, we show that the kainate receptor antagonist LY382884 (10 microM) is selective for… (More)

A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission

Vernon R. J. Clarke, Barbara Ann Ballyk, +12 authors David Bleakman
Nature
1997

The principal excitatory neurotransmitter in the vertebrate central nervous system, L-glutamate, acts on three classes of ionotripic glutamate receptors, named after the agonists AMPA… (More)

Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus

Thomas E. Bartlett, Neil J. Bannister, +7 authors David Lodge
Neuropharmacology
2007

The role of NMDA receptors in the induction of long-term potentiation (LTP) and long-term depression (LTD) is well established but which particular NR2 subunits are involved in these plasticity… (More)

A Role for Ca2+ Stores in Kainate Receptor-Dependent Synaptic Facilitation and LTP at Mossy Fiber Synapses in the Hippocampus

Sari E Lauri, Zuner Assis Bortolotto, +5 authors Graham L Collingridge
Neuron
2003

Compared with NMDA receptor-dependent LTP, much less is known about the mechanism of induction of NMDA receptor-independent LTP; the most extensively studied form of which is mossy fiber LTP in the… (More)

The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus

Michel Vignes, Vernon R. J. Clarke, +4 authors Graham L Collingridge
Neuropharmacology
1998

Activation of kainate receptors depresses excitatory synaptic transmission in the hippocampus. In the present study, we have utilised a GluR5 selective agonist, ATPA… (More)

Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan).

C. G. Parsons, Richard Gruner, Jack Rozental, Julian Millar, David Lodge
Neuropharmacology
1993

Memantine (1-amino-3,5-dimethyladamantan) was tested as an antagonist of N-methyl-D-aspartate (NMDA) receptors on cultured superior collicular and hippocampal neurones using the patch clamp technique… (More)

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.

Nabil A. Anis, Stephanie C. Berry, N. R. Burton, David Lodge
British journal of pharmacology
1983

The interaction of two dissociative anaesthetics, ketamine and phencyclidine, with the responses of spinal neurones to the electrophoretic administration of amino acids and acetylcholine was studied… (More)

DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists

Stephen M Fitzjohn, Ann E. Kingston, David Lodge, Graham L Collingridge
Neuropharmacology
1999

We have used extracellular microelectrode recording to characterise a form of long-term depression (LTD) of synaptic transmission that can be induced by metabotropic glutamate (mGlu) receptor… (More)

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