David Leon Gil

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Formation of the 30S initiation complex (30S IC) is an important checkpoint in regulation of gene expression. The selection of mRNA, correct start codon, and the initiator fMet-tRNA(fMet) requires the presence of three initiation factors (IF1, IF2, IF3) of which IF3 and IF1 control the fidelity of the process, while IF2 recruits fMet-tRNA(fMet). Here we(More)
RuvBL1 and RuvBL2, also known as Pontin and Reptin, are AAA+ proteins essential in small nucleolar ribonucloprotein biogenesis, chromatin remodelling, nonsense-mediated messenger RNA decay and telomerase assembly, among other functions. They are homologous to prokaryotic RuvB, forming single- and double-hexameric rings; however, a DNA binding domain II(More)
The mitochondrial replicative helicase Twinkle is involved in strand separation at the replication fork of mitochondrial DNA (mtDNA). Twinkle malfunction is associated with rare diseases that include late onset mitochondrial myopathies, neuromuscular disorders and fatal infantile mtDNA depletion syndrome. We examined its 3D structure by electron microscopy(More)
The National Institute of Standards and Technology (NIST) certify a variety of Standard Reference Materials (SRMs) to address specific aspects of instrument performance for divergent beam diffractometers. This report describes SRM 640d, the fifth generation of this powder diffraction SRM which is certified with respect to lattice parameter. It consists of(More)
1 Preface This is a preliminary note of some numerical experiments; the results may be rather wrong. 2 Introduction This paper presents the results of numerical experiments to determine the probability, over concrete fixed finite fields, of prime-order elliptic curves having a prime-order twist. These curves are called " elliptic twins " by [7], and are(More)
Breast cancer is a leading cause of cancer-associated death worldwide. One of the most important prognostic factors for survival is the early detection of the disease. Recent studies indicate that extracellular vesicles may provide diagnostic information for cancer management. We demonstrate the secretion of extracellular vesicles by primary breast(More)
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