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Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists
BackgroundDNA methylation and histone acetylation are epigenetic modifications that act as regulators of gene expression. Aberrant epigenetic gene silencing in tumours is a frequent event, yet the… Expand
BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer
- M. Wong, Cecilia Nordfors, +5 authors R. Scott
- Biology, Medicine
- Breast Cancer Research and Treatment
- 16 March 2011
Mutations in the recognized breast cancer susceptibility genes BRCA1, BRCA2, TP53, ATM, and CHEK2 account for approximately 20% of hereditary breast cancer. This raises the possibility that mutations… Expand
Long Term Transcriptional Reactivation of Epigenetically Silenced Genes in Colorectal Cancer Cells Requires DNA Hypomethylation and Histone Acetylation
Epigenetic regulation of genes involves the coordination of DNA methylation and histone modifications to maintain transcriptional status. These two features are frequently disrupted in malignancy… Expand
Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.
- C. Oldmeadow, David L. Mossman, +7 authors R. Scott
- Biology, Medicine
- Journal of psychiatric research
- 1 May 2014
Schizophrenia has a strong genetic basis, and genome-wide association studies (GWAS) have shown that effect sizes for individual genetic variants which increase disease risk are small, making… Expand
Genotyping of urogenital Chlamydia trachomatis in Regional New South Wales, Australia.
From the *Immunology and Infectious Diseases Unit, John Hunter Hospital, Newcastle, Australia; School of Biomedical Sciences, The University of Newcastle, Callaghan, Australia; Institute of Health… Expand
Gene Expression Profiling of Human Myeloid Leukemic MV4-11 Cells Treated with 5-Aza-2’-deoxycytidine
The pyrimidine analog, 5-aza-2’-deoxycytidine (5-aza-dC) is a DNA methyltransferase inhibitor that triggers DNA demethylation leading to the reactivation of epigenetically silenced tumor suppressor… Expand
Methyl-Donor and Cofactor Nutrient Intakes in the First 2–3 Years and Global DNA Methylation at Age 4: A Prospective Cohort Study
Background: During the early postnatal period, the impact of nutrition on DNA methylation has not been well studied in humans. The aim was to quantify the relationship between one-carbon metabolism… Expand
Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross‐sectional study
Accumulating evidence suggests that breastfeeding exclusivity and duration are positively associated with child cognition. This study investigated whether DNA methylation, an epigenetic mechanism… Expand
Epimutations, Inheritance and Causes of Aberrant DNA Methylation in Cancer
Epigenetic aberrations such as global hypomethylation and gene-specific hypermethylation are key events that underlie tumour development. Such scenarios are brought about by the loss of control of… Expand
Hunter Cancer Research Alliance Annual Symposium 2015.