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A new version of the Community Atmosphere Model (CAM) has been developed and released to the climate community. CAM Version 3 (CAM3) is an atmospheric general circulation model that includes the Community Land Model (CLM3), an optional slab ocean model, and a thermodynamic sea ice model. The dynamics and physics in CAM3 have been changed substantially(More)
All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth advantage and are implicated in cancer development, whereas the remainder are passengers. Here we have sequenced the genomes of a malignant melanoma and a lymphoblastoid cell line from the same person, providing the first(More)
A new version of the Community Atmosphere Model (CAM) has been developed and released to the climate community. CAM3 is an atmospheric general circulation model that includes the Community Land Model (CLM3), an optional slab-ocean model, and a thermodynamic sea-ice model. The dynamics and physics in CAM3 have been changed substantially compared to(More)
Remodeling of filamentous actin into distinct arrangements is precisely controlled by members of the Rho family of small GTPases [1]. A well characterized member of this family is RhoA, whose activation results in reorganization of the cytoskeleton into thick actin stress fibers terminating in integrin-rich focal adhesions [2]. Regulation of RhoA is(More)
SUMMARY A deterministic initial-value test case for dry dynamical cores of atmospheric general-circulation models is presented that assesses the evolution of an idealized baroclinic wave in the northern hemisphere. The initial zonal state is quasi-realistic and completely defined by analytic expressions which are a steady-state solution of the adiabatic(More)