Carl H June2
Alison Loren2
Jacqueline Smith2
Steven C Goldstein2
Michael Kalos2
2Carl H June
2Alison Loren
2Jacqueline Smith
2Steven C Goldstein
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We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen receptor) signaling domains. A low dose (approximately 1.5×10(5) cells per kilogram of body weight) of(More)
  • Alison Rager, Noelle Frey, Steven C Goldstein, Ran Reshef, Elizabeth O Hexner, Alison Loren +8 others
  • 2011
Treatment options for steroid-refractory GVHD (SR-GVHD) are unsatisfactory and prognosis is poor. Inflammatory cytokines IL-2 and TNF-α are important mediators of GVHD, and may be critical targets for therapy. We retrospectively reviewed our experience using combination anti-cytokine therapy of daclizumab and infliximab. Seventeen evaluable patients had a(More)
  • Marco Ruella, David M Barrett, Saad S Kenderian, Olga Shestova, Ted J Hofmann, John Scholler +10 others
  • 2015
Introduction Anti-CD19 chimeric antigen receptor T cells (CART19) and bi-specific anti-CD19/CD3 antibodies (blinatumo-mab) are generating unprecedented complete responses in relapsing/refractory B-cell acute lymphoblastic leuke-mia (r/r BALL). However, a subset of patients still relapse and about 30-50% of these relapses are characterized by the loss of(More)
  • Vikram R. Paralkar, Sunita Dwivedy Nasta, Kelly Morrissey, Jacqueline Smith, Pavel Vassilev, Mary Ellen Martin +5 others
  • 2012
Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of non-Hodgkin lymphomas that are considered incurable. The role of allogeneic hematopoietic stem cell transplantation (HSCT) in the treatment of CTCL is not well defined but may provide potent graft-vs-lymphoma (GVL) activity independent of the conditioning therapy. We present outcomes of 12(More)
Micropsectra sedna (Oliver, 1976) is a parthenogenetic midge from the Canadian Arctic. The parthenogenetic mechanism is apomictic thelytoky, with a restitutional division during oogenesis, as found in other parthenogenetic Chironomidae. It is triploid, with two similar chromosome sets, and the third is relatively dissimilar, pairing little with the diploid(More)
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