David L Marcus

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The overall peroxidation activity in brain tissue by region from patients with Alzheimer's disease (AD) and age-matched controls was determined employing the thiobarbituric acid-reactive substances (TBARS) assay, a measure of lipid peroxidation, followed by a determination the activities of the antioxidant enzymes Cu/Zn superoxide dismutase (SOD),(More)
BACKGROUND Manganese-dependent superoxide dismutase (MnSOD) is a major defense mechanism against potential cellular damage by reactive oxygen species (ROS). We have reported increased lipid peroxidation and decreased Cu/Zn SOD enzymatic activity in the temporal cortex of Alzheimer's diseased (AD) brains. MATERIAL/METHODS We now report the expression of(More)
Apoptosis, or programmed cell death, has been proposed as a mechanism of neuropathology in Alzheimer's disease (AD). Activation of immediate early genes (IEG) c-jun and c-fos appears to be required for the initiation of apoptosis. Furthermore, the expression of c-jun is induced in cultured neurons that undergo beta-amyloid-mediated apoptosis suggesting a(More)
Isolated mitochondria from rat livers of various ages show a gradual decline in the rate of inner membrane-matrix protein synthesis with advancing age of the animal. Rats at 112-120 weeks synthesize these proteins at only 40% of the rate of 2-8-week-old animals. The initial rates of incorporation of label were 145 cpm/mg/minute for the "old" animals, and(More)
Riege and Metter provide a useful review of the application of PET in the evaluation of Alzheimer's disease (AD). We share their enthusiasm for continued support and development of tools to image metabolic processes. Our commentary focuses on neuroimaging and the diagnosis of AD and introduces some new data that directly impacts on the interpretation of(More)
Mitochondria isolated from the livers of old rats (26-30 months) were found to incorporate 41% less leucine into mitochondrial proteins as compared to those from young rats (2-3 months). The initial rates of incorporation of label were 145 cpm/mg/min for the "old" animals, and 320 cpm/mg/min for the young animal. No difference in either amino acid pool size(More)
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