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From REACCS, to MDL ISIS/Host Reaction Gateway, and most recently to MDL Relational Chemistry Server, a new product based on Oracle data cartridge technology, MDL's reaction database management and retrieval systems have undergone great changes. The evolution of the system architecture is briefly discussed. The evolution of MDL reaction substructure search(More)
BACKGROUND The differential diagnosis of a neonate or fetus presenting with a bell-shaped or long narrow thorax includes a wide range of bony dysplasia syndromes. Where this is accompanied by respiratory distress, asphyxiating thoracic dystrophy (ATD, Jeune syndrome) is an important potential diagnosis. Shwachman-Diamond syndrome (SDS) is widely recognised(More)
The Association of Community Colleges of Canada (ACCC), with funding from Agriculture and Agri-Food Canada, embarked on a study to identify innovative practices in agricultural learning. The project team (Rick Tofani of Olds College Centre for Innovation of Olds Alberta and David Grier and Jennifer Haskey of the Saskatchewan Research Council) were directed(More)
The wide application of next-generation sequencing has presented a new hurdle to bioinformatics for managing the fast-growing sequence data. The management of biomacromolecules at the chemistry level imposes an even greater challenge in cheminformatics because of the lack of a good chemical representation of biopolymers. Here we introduce the self-contained(More)
Biomolecules present challenges to chemical information systems designed for small molecules. Their sizes, up to tens of thousands of atoms, overwhelm representation/ storage/searching solutions built on explicit chemical representation of the structures. But biomolecules are largely made up of many repeats of a limited number of building-block molecules, a(More)
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