David L Bennett

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A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury.

David L Bennett, Gregory J Michael, +5 authors John V. Priestley
The Journal of neuroscience : the official…
1998

Several lines of evidence suggest that neurotrophin administration may be of some therapeutic benefit in the treatment of peripheral neuropathy. However, a third of sensory neurons do not express… (More)

Potent analgesic effects of GDNF in neuropathic pain states.

Timothy J Boucher, Kenji Okuse, David L Bennett, J. B. Munson, John N Wood, Stephen B. McMahon
Science
2000

Neuropathic pain arises as a debilitating consequence of nerve injury. The etiology of such pain is poorly understood, and existing treatment is largely ineffective. We demonstrate here that glial… (More)

Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord.

Gregory J Michael, Sharon A Averill, +4 authors John V. Priestley
The Journal of neuroscience : the official…
1997

Using immunocytochemistry and in situ hybridization, we have examined the expression of brain-derived neurotrophic factor (BDNF) and of neurotrophin receptors in dorsal root ganglion cells. In the… (More)

Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord.

Bradley J Kerr, Elizabeth J. Bradbury, +6 authors Stephen W.N. Thompson
The Journal of neuroscience : the official…
1999

Central sensitization, the hyperexcitability of spinal processing that often accompanies peripheral injury, is a major component of many persistent pain states. Here we report that the neurotrophin,… (More)

Behavioral Thermoregulation and Slowed Migration by Adult Fall Chinook Salmon in Response to High Columbia River Water Temperatures

THOMAS M. GONIEA, Matthew L Keefer, THEODORE C. BJORNN, Christopher A. Peery, David L Bennett, Lowell C. Stuehrenberg
2006

—The relationships between lower Columbia River water temperatures and migration rates, temporary tributary use, and run timing of adult fall Chinook salmon Oncorhynchus tshawytscha were studied… (More)

Conduction failure following spinal cord injury: functional and anatomical changes from acute to chronic stages.

Nicholas D James, Katalin Bartus, John Grist, David L Bennett, Stephen B. McMahon, Elizabeth J. Bradbury
The Journal of neuroscience : the official…
2011

In the majority of spinal cord injuries (SCIs), some axonal projections remain intact. We examined the functional status of these surviving axons since they represent a prime therapeutic target.… (More)

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

Barbara Kremeyer, Francisco Lopera, +17 authors Andres Ruiz-Linares
Neuron
2010

Human monogenic pain syndromes have provided important insights into the molecular mechanisms that underlie normal and pathological pain states. We describe an autosomal-dominant familial episodic… (More)

The role of the immune system in the generation of neuropathic pain

Margarita Calvo, John M. Dawes, David L Bennett
The Lancet Neurology
2012

Persistent pain is a sequela of several neurological conditions with a primary immune basis, such as Guillain-Barré syndrome and multiple sclerosis. Additionally, diverse forms of injury to the… (More)

Neuroinflammation and the generation of neuropathic pain.

Anthony Ellis, David L Bennett
British journal of anaesthesia
2013

Inflammation is the process by which an organism responds to tissue injury involving both immune cell recruitment and mediator release. Diverse causes of neuropathic pain are associated with… (More)

Postnatal changes in the expression of the trkA high-affinity NGF receptor in primary sensory neurons.

David L Bennett, Sharon A Averill, Douglas O. Clary, John V. Priestley, Stephen B. McMahon
The European journal of neuroscience
1996

In development approximately 70-80% of dorsal root ganglion (DRG) cells are dependent on nerve growth factor (NGF) for their survival, while in the adult only some 40% of DRG cells express the… (More)

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