David Knipe

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Executive Summary The related areas of chemical biology, pharmacology, and therapeutics afford enormous opportunities for innovation in education, research, and treatment of disease. There are major strengths in these areas at Harvard on which to build, particularly in basic biology and clinical research, and pockets of strength in therapeutically relevant(More)
RIG-I detects double-stranded RNA (dsRNA) to trigger antiviral cytokine production. Protein deamidation is emerging as a post-translational modification that chiefly regulates protein function. We report here that UL37 of herpes simplex virus 1 (HSV-1) is a protein deamidase that targets RIG-I to block RNA-induced activation. Mass spectrometry analysis(More)
The proper maintenance of the pathways governing cell growth is critical to ensure cell survival and DNA fidelity. Much of our understanding of how the cell cycle is regulated comes from studies examining the relationship between DNA viruses and the mechanisms of cell proliferation control. There are numerous examples demonstrating that viruses can alter(More)
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