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  • David Kleinfeld, Partha P. Mitra, Fritjof Helmchen, Winfried Denk
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 1998 (First Publication: 22 December 1998)
  • Cortical blood flow at the level of individual capillaries and the coupling of neuronal activity to flow in capillaries are fundamental aspects of homeostasis in the normal and the diseased brain. ToContinue Reading
  • John Y. Lin, Per Magne Knutsen, Arnaud C. A. Muller, David Kleinfeld, Roger Tsien
  • Biology, Medicine
  • Nature Neuroscience
  • 2013 (First Publication: 1 September 2013)
  • Channelrhodopsins (ChRs) are used to optogenetically depolarize neurons. We engineered a variant of ChR, denoted red-activatable ChR (ReaChR), that is optimally excited with orange to red light (λContinue Reading
  • Philbert S. Tsai, John P. Kaufhold, +5 authors David Kleinfeld
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 2009 (First Publication: 18 November 2009)
  • It is well known that the density of neurons varies within the adult brain. In neocortex, this includes variations in neuronal density between different lamina as well as between different regions.Continue Reading
  • Michale S. Fee, Partha P. Mitra, David Kleinfeld
  • Computer Science, Medicine
  • Journal of Neuroscience Methods
  • 1996 (First Publication: 1 November 1996)
  • Neuronal noise sources and systematic variability in the shape of a spike limit the ability to sort multiple unit waveforms recorded from nervous tissue into their single neuron constituents. Here weContinue Reading
  • Pablo Blinder, Philbert Tsai, John P. Kaufhold, Per Magne Knutsen, Harry Suhl, David Kleinfeld
  • Medicine, Biology
  • Nature Neuroscience
  • 2013 (First Publication: 1 July 2013)
  • What is the nature of the vascular architecture in the cortex that allows the brain to meet the energy demands of neuronal computations? We used high-throughput histology to reconstruct the completeContinue Reading
  • Anna Devor, Peifang A. Tian, +7 authors Anders M. Dale
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 2007 (First Publication: 18 April 2007)
  • Synaptic transmission initiates a cascade of signal transduction events that couple neuronal activity to local changes in blood flow and oxygenation. Although a number of vasoactive molecules andContinue Reading