David Kinderlehrer

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Intracellular transport in eukarya is attributed to motor proteins that transduce chemical energy into directed mechanical motion. Nanoscale motors like kinesins tow organelles and other cargo on microtubules or filaments, have a role separating the mitotic spindle during the cell cycle, and perform many other functions. The simplest description gives rise(More)
Intracellular transport in eukarya is attributed to motor proteins that transduce chemical energy into directed mechanical motion. Muscle myosin has been known since the mid nineteenth century and its role in muscle contraction demonstrated by A. F. Huxley and H. E. Huxley in the 1950's. Kinesins and their role in intracellular transport were discovered(More)
A mesoscale, variational simulation of grain growth in two-dimensions has been used to explore the effects of grain boundary properties on the grain boundary character distribution. Anisotropy in the grain boundary energy has a stronger influence on the grain boundary character distribution than anisotropy in the grain boundary mobility. As grain growth(More)
Most technologically useful materials arise as polycrystalline microstructures, composed of a myriad of small crystallites, called grains, separated by their interfaces, called grain boundaries. The orientations and arrangements of the grains and their network of boundaries are implicated in many properties across wide scales, for example, functional(More)
Relative grain boundary energy as a function of misorientation angle has been measured in cube-oriented, i.e., <100> fiber-textured, 120 μm-thick Al foil using orientation imaging microscopy and a statistical multiscale method. The energies of low-angle boundaries increase with misorientation angle, in good agreement with the Read-Shockley model. The(More)
Diffusion mediated transport is a phenomenon in which a unidirectional motion of particles is achieved as a result of two opposing tendencies: diffusion, which spreads the particles uniformly through the medium and transport, which concentrates the particles at some special sites. The flashing ratchet version of the Brownian motor, a simple model for(More)