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  • Lorna H Mitchell, Theodore R. Johnson, +14 authors David Joseph Pocalyko
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2010 (First Published: 10 June 2010)
  • A novel nonsteroidal androgen receptor antagonist, (R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-2-(trifluoromethyl)benzonitrile (1), for the topical control of sebum production is reported.Continue Reading
  • Lain-Yen Hu, Daniel Yunlong Du, +28 authors Howard G. Welgus
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2007 (First Published: 1 November 2007)
  • Synthesis, pharmacology, and pharmacokinetic profiles of (1R, 2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile are reported. This compound demonstrated remarkable potency for stimulatingContinue Reading
  • Lorna H Mitchell, Zhi Wang, +6 authors Kimberly J Wade
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2009 (First Published: 1 March 2009)
  • The first examples of thioether-substituted benzonitriles as potential soft-drug androgen receptor antagonists are reported. A number of 4-(alkylthio)- and of 4-(arylthio)-benzonitrile analogs wereContinue Reading