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Background In haemodynamically stable patients with acute symptomatic pulmonary embolism (PE), studies have not evaluated the usefulness of combining the measurement of cardiac troponin, transthoracic echocardiogram (TTE), and lower extremity complete compression ultrasound (CCUS) testing for predicting the risk of PE-related death. Methods The study(More)
During cortical development, different cell populations arise in the basal telencephalon and subsequently migrate tangentially to the neocortex. However, it is not clear whether these cortical cells are generated in the lateral ganglionic eminence (LGE), the medial ganglionic eminence (MGE), or both. In this study, we have generated a three-dimensional(More)
Using birthdating techniques, we have studied when cells that settle in the marginal zone (future layer 1) of the cortical neuroepithelium are generated in developing rat embryos. The majority of marginal zone cells are generated at embryonic day 12 (E12), E13 and E14, although some cells generated later can incorporate into this stratum after the cortical(More)
The White Noise Hypothesis (WNH) assumes that in the uniform pulse code modulation (PCM) quantization scheme the errors in individual channels behave like white noise, i.e. they are independent and identically distributed random variables. The WNH is key to estimating the mean square quantization error (MSE). But is the WNH valid? In this paper we take a(More)
BACKGROUND Optimal management of acute pulmonary embolism (PE) requires medical expertise, diagnostic testing, and therapies that may not be available consistently throughout the entire week. We sought to assess whether associations exist between weekday or weekend admission and mortality and length of hospital stay for patients hospitalized with PE. (More)
Centerline tracing of dendritic structures in confocal images of neurons is an essential tool for the construction of a geometric representation of a neuronal network. In this paper, we propose a novel algorithm (ORION 2) for centerline extraction that is both highly accurate and computationally efficient. The main novelty of the proposed method is the use(More)
The automated reconstruction of neuronal morphology is a fundamental task for investigating several problems associated with the nervous system. Revealing the mechanisms of synaptic plasticity, signal transmission, network connectivity and circuit dynamics requires accurate quantitative analyses of digital three-dimensional reconstructions. Yet, while many(More)