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Data analysis is an important functionality in cloud computing which allows a huge amount of data to be processed over very large clusters. MapReduce is recognized as a popular way to handle data in the cloud environment due to its excellent scalability and good fault tolerance. However, compared to parallel databases, the performance of MapReduce is slower(More)
CONTEXT Targeting MAPK kinase (MEK) in the MAPK pathway is a potentially effective therapeutic strategy for thyroid cancer. OBJECTIVE The objective of the study was to investigate genotype-dependent therapeutic potential of the MEK inhibitor CI-1040 for thyroid cancer. EXPERIMENTAL DESIGN We examined the effects of CI-1040 on proliferation, apoptosis,(More)
PURPOSE The V600E BRAF mutant plays an important role in the pathogenesis of papillary thyroid cancer (PTC) and is associated with loss of expression of thyroid iodide-metabolizing genes. This study was done to investigate the restorability of expression of these genes by suppressing the BRAF/extracellular signal-regulated kinase kinase(More)
The extracellular matrix (ECM) is one of the most important components within the tumor microenvironment that supports cancer development and metastasis. Under normal physiological conditions, the ECM is a tightly regulated network providing structural and biochemical support. However, the ECM becomes highly disorganized during neoplastic progression and(More)
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