David Jacques Cohen

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The relevance of central neurotransmission to aggressive and impulsive behavior has become more evident due to extensive research in humans and animals. Among other findings, there are abundant data relating low serotonergic activity--as measured by low cerebrospinal fluid 5-hydroxyindolacetic acid, and a blunted response of prolactin to fenfluramine--to(More)
Efficacy and safety of the coadministration of tadalafil once daily with finasteride for 6 months in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia. Editorial Comment: Since the launch of the 5-alpha reductase inhibitor finasteride in 1992, medical management of lower urinary tract symptoms (LUTSs)(More)
Over the past decade we have begun to understand the molecular and genetic underpinnings of Peyronie's disease (PD). We now know that the transforming growth factor (TGF)-β signaling pathway is one of the major contributors to aberrant fibrosis in PD, and are beginning to understand that other pathways, including the Wnt/β-catenin and mitogen-activated(More)
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