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Topiramate (TPM) has shown efficacy in migraine prophylaxis in two large placebo-controlled, dose-ranging trials. We conducted a randomised, double-blind, multicentre trial to evaluate the efficacy and safety of two doses of topiramate vs placebo for migraine prophylaxis, with propranolol (PROP) as an active control. Subjects with episodic migraine with and(More)
BACKGROUND Open-label trials and small controlled studies report topiramate's efficacy in migraine prevention. OBJECTIVE To assess the efficacy and safety of topiramate as a migraine-preventive therapy. DESIGN A 26-week, randomized, double-blind, placebo-controlled study. SETTING Outpatient treatment at 49 US clinical centers. Patients Patients were(More)
Poorly maintained sidewalks, missing curb ramps, and other obstacles pose considerable accessibility challenges. Although pedestrian-and bicycle-oriented maps and associated routing algorithms continue to improve, there has been a lack of work focusing on accessibility. There is currently no way for a user to determine accessible areas of a city prior to(More)
As the web becomes the application platform of choice, supporting complex authorization policies is becoming increasingly difficult. This paper discusses the security challenges that web applications must face. It then proposes an authorization framework to help address those challenges. It provides some examples of how various policies can be implemented(More)
Face recognition is a challenging problem, complicated by variations in pose, expression, lighting, and the passage of time. Significant work has been done to solve each of these problems separately. We consider the problems of lighting and expression variation together, proposing a method that accounts for both variabilities within a single model. We(More)
DISCLAIMER The views, opinions and/or findings contained in this report are those of The MITRE Corporation and should not be construed as an official Government position, policy, or decision, unless designated by other documentation. This report documents the results of a short email-mediated study by The MITRE Corporation on the use of free and open-source(More)
Building on recent prior work that combines Google Street View (GSV) and crowdsourcing to remotely collect information on physical world accessibility, we present the first 'smart' system, Tohme, that combines machine learning, computer vision (CV), and custom crowd interfaces to find curb ramps remotely in GSV scenes. Tohme consists of two workflows, a(More)
The views, opinions and/or findings contained in this report are those of The MITRE Corporation and should not be construed as an official Government position, policy, or decision, unless designated by other documentation. Abstract This report documents research efforts for the FY03 and FY04 Mission Oriented Investigation and Experimentation (MOIE) project(More)
We address the problem of searching camera network videos to retrieve frames containing specified individuals. We show the benefit of utilizing a learned probabilistic model that captures dependencies among the cameras. In addition, we develop an active inference framework that can request human input at inference time, directing human attention to the(More)