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- S G Yan, Tomoyuki Fujita, +5 authors David M. Stern
- Nature Medicine
- 2000
Activation of the zinc-finger transcription factor early growth response (Egr)-1, initially linked to developmental processes, is shown here to function as a master switch activated by ischemia to… (More)
- Wen Ning, Chaojun Li, +14 authors Augustine M. K. Choi
- Proceedings of the National Academy of Sciences…
- 2004
To better understand the molecular basis of chronic obstructive pulmonary disease (COPD), we used serial analysis of gene expression (SAGE) and microarray analysis to compare the gene expression… (More)
- Vibha N Lama, Lisa M. Smith, +11 authors Victor J Thannickal
- The Journal of clinical investigation
- 2007
The origin and turnover of connective tissue cells in adult human organs, including the lung, are not well understood. Here, studies of cells derived from human lung allografts demonstrate the… (More)
- Tomoyuki Fujita, Koichi Toda, +4 authors David J. Pinsky
- Nature Medicine
- 2001
Carbon monoxide (CO) can arrest cellular respiration, but paradoxically, it is synthesized endogenously by heme oxygenase type 1 (Ho-1) in response to ischemic stress. Ho-1–deficient (Hmox1−/−) mice… (More)
- S F Yan, Jian-yi Lu, +8 authors David M. Stern
- The Journal of biological chemistry
- 1999
The paradigm for the response to hypoxia is erythropoietin gene expression; activation of hypoxia-inducible factor-1 (HIF-1) results in erythropoietin production. Previously, we found that oxygen… (More)
- E Sander Connolly, Christopher J. Winfree, David M. Stern, Robert A. Solomon, David J. Pinsky
- Neurosurgery
- 1996
The recent availability of transgenic mice has led to a burgeoning number of reports describing the effects of specific gene products on the pathophysiology of stroke. Although focal cerebral… (More)
- J D Mocco, William J. Mack, +10 authors E. Sander Connolly
- Circulation research
- 2006
The complement cascade has been implicated in ischemia/reperfusion injury, and recent studies have shown that complement inhibition is a promising treatment option for acute stroke. The development… (More)
- David J. Pinsky, M. Johan Broekman, +14 authors Charles R. Maliszewski
- The Journal of clinical investigation
- 2002
Endothelial CD39 metabolizes ADP released from activated platelets. Recombinant soluble human CD39 (solCD39) potently inhibited ex vivo platelet aggregation in response to ADP and reduced cerebral… (More)
- David J. Pinsky, Yoshihisa Naka, +6 authors David M. Stern
- Proceedings of the National Academy of Sciences…
- 1994
Reestablishment of vascular homeostasis following ex vivo preservation is a critical determinant of successful organ transplantation. Because the nitric oxide (NO) pathway modulates pulmonary… (More)
- Keisuke Kuwabara, Sumito Ogawa, +7 authors Jacquelyn Joseph-Silverstein
- Proceedings of the National Academy of Sciences…
- 1995
Wound repair and tumor vascularization depend upon blood vessel growth into hypoxic tissue. Although hypoxia slows endothelial cell (EC) proliferation and suppresses EC basic fibroblast growth factor… (More)