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Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
The genetic lesion underlying familial British dementia (FBD), an autosomal dominant neurodegenerative disorder, is a T–A transversion at the termination codon of the BRI gene. The mutant geneExpand
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Between local innovation and global impact: cities, networks, and the governance of climate change
Global climate governance conducted in settings such as the United Nations Framework Convention on Climate Change (UNFCCC), Major Economies Forum, and Group of Twenty (G20) has proven incapable, toExpand
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A Critical History of Mindfulness-Based Psychology
Acknowledgements Over the past few months I've been asked a number of questions about my thesis. A common question has been: " Well, are you being mindful while writing about mindfulness? " I'd likeExpand
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Gene expression signature based screening identifies ribonucleotide reductase as a candidate therapeutic target in Ewing sarcoma
There is a critical need in cancer therapeutics to identify targeted therapies that will improve outcomes and decrease toxicities compared to conventional, cytotoxic chemotherapy. Ewing sarcoma is aExpand
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Drug conjugated nanoparticles activated by cancer cell specific mRNA
We describe a customizable approach to cancer therapy in which a gold nanoparticle (Au-NP) delivers a drug that is selectively activated within the cancer cell by the presence of an mRNA unique toExpand
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Inhibition of the ATR–CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2
Inhibition of ribonucleotide reductase (RNR), the rate-limiting enzyme in the synthesis of deoxyribonucleotides, causes DNA replication stress and activates the ataxia telangiectasia and rad3-relatedExpand
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mTORC1/2 and Protein Translation Regulate Levels of CHK1 and the Sensitivity to CHK1 Inhibitors in Ewing Sarcoma Cells
The treatment of Ewing sarcoma has changed very little in the past two decades and novel treatment approaches are needed. We recently identified that Ewing sarcoma cells are uniquely vulnerable toExpand
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Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine.
Ewing sarcoma is a bone and soft tissue sarcoma that occurs in children and young adults. The EWS-FLI1 gene fusion is the driver mutation in most Ewing sarcoma tumors and functions, in part, as anExpand
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Pharmacologic Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage
The clinical potential of pharmacologic ascorbate (P-AscH−; intravenous delivery achieving mmol/L concentrations in blood) as an adjuvant in cancer therapy is being reevaluated. At mmol/LExpand
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SN-38 Conjugated Gold Nanoparticles Activated by Ewing Sarcoma Specific mRNAs Exhibit In Vitro and In Vivo Efficacy.
The limited delivery of chemotherapy agents to cancer cells and the nonspecific action of these agents are significant challenges in oncology. We have previously developed a customizable drugExpand
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