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  • Christiane Riedinger, Martin E. M. Noble, +4 authors James M McDonnell
  • Chemistry, Medicine
  • Chemical biology & drug design
  • 2011 (First Published: 1 May 2011)
  • The interaction between murine double minute (MDM2) and p53 is a major target in anticancer drug design. Several potent compound series, including the nutlins and spirooxindoles, have previously beenContinue Reading
  • Ryan Matthew Harrington, David J Wright, Samir Z Zard
  • Chemistry
  • 2012 (First Published: 31 December 2012)
  • Propargyl xanthates undergo rearrangement to afford intermediary bis(alkylidene)dithiolanones which are trapped by Diels-Alder cycloaddition to yield dithiolones, representing three new carbocycleContinue Reading