David J Wooten

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We retrospectively reviewed 3 679 pediatric records from King/Drew Medical Center, south central Los Angeles, between 1991 and 1994. Blood lead levels of children were followed to age 18 y. Patients were not referred specifically for lead poisoning. The sample was primarily Latino. Geometric mean blood lead peaked at 6.7 micrograms/dl (0.32 mumol/l) between(More)
BACKGROUND AND OBJECTIVES Factors governing the spread of local anesthetic in the subarachnoid space have been controversial because of failure to consider the drug related and physical factors. Most studies of isobaric spinal anesthesia in the literature were made using plain bupivacaine which is slightly hypobaric. In this study the effects of drug dose,(More)
Airway obstruction remains a constant problem in acute care. This is particularly true when there are anatomical or pathological abnormalities, trauma, or when repeated failed attempts at endoscopic or blind intubations have left a bloody field, preventing clear visualization of the vocal cords. Our refinement of translaryngeal guided intubation (TLI) uses(More)
To assess the adequacy of the general anesthesia commonly employed for Cesarean section, we used isolated forearm technique to study 30 parturients (physical status ASA I/II, aged 17-35 yr) scheduled for nonemergent abdominal delivery. Anesthesia was induced with intravenous thiopental (3 mg/kg, 250 mg maximum) and succinylcholine (1.5 mg/kg), and then(More)
Sir,—In a recent report, Hirabayashi and colleagues [1] showed that subarachnoid administration of hyperbaric amethocaine (tetracaine) produced an unexpectedly higher level of analgesia in adolescents than in adults. The authors postulated that when adolescents lie in the supine horizontal position, the thoracic kyphotic curvature decreases because of the(More)
Small cell lung cancer (SCLC) is a devastating disease due to its propensity for early invasion and refractory relapse after initial treatment response. Although these aggressive traits have been associated with phenotypic heterogeneity, our understanding of this association remains incomplete. To fill this knowledge gap, we inferred a set of 33(More)
Glycerin has been used as a drug carrier/depot, but never with local anaesthetics. This study was an attempt to use the slow drug release mechanism to prolong the anaesthetic effects of bupivacaine in epidural block. Twenty-seven adults with cancer pain were prospectively selected according to their primary lesions and problems, but their allocation to(More)
A cell's phenotype is the observable actualization of complex interactions between its genome, epigenome, and local environment. While traditional views in cancer have held that cellular and tumor phenotypes are largely functions of genomic instability, increasing attention has recently been given to epigenetic and microenvironmental influences. Such(More)