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BACKGROUND Among patients with a proximal vessel occlusion in the anterior circulation, 60 to 80% of patients die within 90 days after stroke onset or do not regain functional independence despite alteplase treatment. We evaluated rapid endovascular treatment in addition to standard care in patients with acute ischemic stroke with a small infarct core, a(More)
Although the basal ganglia play an important role in self-generated movement, their involvement in externally paced voluntary movement is less clear. We recorded local field potentials (LFPs) from the region of the subthalamic nuclei of eight patients with Parkinson's disease during the performance of a warned reaction time task in which an imperative cue(More)
BACKGROUND Women with gestational diabetes are at increased risk of developing type 2 diabetes, but the risk and time of onset have not been fully quantified. We therefore did a comprehensive systematic review and meta-analysis to assess the strength of association between these conditions and the effect of factors that might modify the risk. METHODS We(More)
Functional neurosurgery in patients with movement disorders has provided a unique opportunity to record directly form the human basal ganglia (BG) and to thereby further our understanding of these 'dark basements of the mind.' Two possibilities exist: either single unit and local field potential (LFP) recordings can be made intra-operatively through(More)
OBJECTIVE To determine if ice-water immersion after eccentric quadriceps exercise minimises the symptoms of delayed-onset muscle soreness (DOMS). DESIGN A prospective randomised double-blind controlled trial was undertaken. 40 untrained volunteers performed an eccentric loading protocol with their non-dominant leg. INTERVENTIONS Participants were(More)
Cadmium is a non-essential element that has high rates of soil to plant transference compared with other non-essential elements, and certain plant species accumulate large amounts of cadmium from low cadmium content soils. In this paper, levels of cadmium found in major food groups are highlighted together with cadmium levels found in liver and kidney(More)
We test the hypothesis that interaction between the human basal ganglia and cerebral cortex involves activity in multiple functional circuits characterized by their frequency of oscillation, phase characteristics, dopamine dependency and topography. To this end we took recordings from macroelectrodes (MEs) inserted into the subthalamic nucleus (STN) in(More)
OBJECTIVE To assess neurocognitive impairment after the off-pump and on-pump techniques for coronary artery bypass graft surgery in patients with triple vessel disease. DESIGN Randomised controlled trial. SETTING University Hospital of Wales, Cardiff. PARTICIPANTS 60 patients undergoing coronary artery bypass graft surgery for triple vessel disease(More)
OBJECTIVE The purpose of this study is to provide measurements of the elastic modulus of the aortic wall of ascending thoracic aortic aneurysms for different ranges of pressure (physiologic, hypertensive). In addition, pre-failure stress, taken as the peak stress obtained before specimen failure, was recorded for each test. METHODS Ninety-seven aortic(More)
Past sun exposure is linked to a wide range of disease outcomes but is difficult to measure accurately. Silicone skin casts measure skin damage, but some studies show that age rather than sun exposure is the most important determinant of cast score. We examined skin damage scores from silicone casts of the back of the hand in a large adult sample (n = 534)(More)