David J. Wheatley

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BACKGROUND Current guidelines suggest that, for patients at moderate risk of death from unstable coronary-artery disease, either an interventional strategy (angiography followed by revascularisation) or a conservative strategy (ischaemia-driven or symptom-driven angiography) is appropriate. We aimed to test the hypothesis that an interventional strategy is(More)
SUMMARY The acute response to stress is embodied in thè®ght or ¯ight reaction', inducing a state of anxiety. When stress is long-continued, depression may develop insidiously under the cloak of continuing anxiety symptoms. Depression inhibits the ability to cope with stress and so a `vicious circle' becomes established, depression aggravating stress and(More)
OBJECTIVE To compare survival and outcome in patients receiving a mechanical or bioprosthetic heart valve prosthesis. DESIGN Randomised prospective trial. SETTING Tertiary cardiac centre. PATIENTS Between 1975 and 1979, patients were randomised to receive either a Bjork-Shiley or a porcine prostheses. The mitral valve was replaced in 261 patients, the(More)
BACKGROUND The long-term outcome of an interventional strategy in patients with non-ST-elevation acute coronary syndrome is unknown. We tested whether an interventional strategy (routine angiography followed by revascularisation) was better than a conservative strategy (ischaemia-driven or symptom-driven angiography) over 5 years' follow-up. METHODS In a(More)
Current artificial heart valves either have limited lifespan or require the recipient to be on permanent anticoagulation therapy. In this paper, effort is made to assess a newly developed bileaflet valve prosthesis made of synthetic flexible leaflet materials, whose geometry and material properties are based on those of the native mitral valve, with a view(More)
BACKGROUND Venous thromboembolism (VTE) is a major health and financial burden. VTE impacts health outcomes in surgical and non-surgical patients. VTE prophylaxis is underutilized, particularly amongst high risk medical patients. We conducted a multicentre clinical audit to determine the extent to which appropriate VTE prophylaxis in acutely ill(More)
This paper describes a method of calculating the inherent visibility at all locations in a landscape ('total viewshed') by making use of redundant computer cycles. This approach uses a simplified viewshed program that is suitable for use within a distributed environment, in this case managed by the Condor system. Distributing the calculation in this way(More)
BACKGROUND AND PURPOSE Doppler emboli detection is an established technique, but the nature of the underlying embolic material remains unclear. The intensity and spectral distribution of emboli signals could help to distinguish between signals arising from formed and gaseous emboli. We undertook this study to develop and evaluate a differentiation algorithm(More)
Interaction with computer based systems long since moved out of the domain of the professional user in the office environment. But now neither is it solely the domain of the naïve but motivated user in the home and office environment. Such interaction with complex applications and services is moving beyond the desktop and into everyday life. New(More)