David J. Wheatley

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SUMMARY The acute response to stress is embodied in thè®ght or ¯ight reaction', inducing a state of anxiety. When stress is long-continued, depression may develop insidiously under the cloak of continuing anxiety symptoms. Depression inhibits the ability to cope with stress and so a `vicious circle' becomes established, depression aggravating stress and(More)
BACKGROUND Venous thromboembolism (VTE) is a major health and financial burden. VTE impacts health outcomes in surgical and non-surgical patients. VTE prophylaxis is underutilized, particularly amongst high risk medical patients. We conducted a multicentre clinical audit to determine the extent to which appropriate VTE prophylaxis in acutely ill(More)
The duration of action of hypnosedative drugs is mainly determined by their pharmacokinetic properties. The ideal drug should induce sleep within 30 min and maintain a normal pattern of sleep for 6 to 8h, with little or no residual effects the next morning. Clinically, 4 types of insomnia can be distinguished: prolonged latency, 1 to 2 long periods of(More)
The car of the future will have many new information sources— including telematics systems, navigation systems and Advanced Driver Assistance Systems (ADAS)—that will compete for a driver's limited cognitive attention. If they are implemented as completely separate systems then cognitive overload and driver distraction are inevitable outcomes. However, if(More)
Heparin, when administered to patients undergoing operations using cardiopulmonary bypass, induces plasma changes that gradually impair platelet macroaggregation, but heparinization of whole blood in vitro does not have this effect. The plasma changes induced by heparin in vivo continue to progress in whole blood ex vivo. Heparin releases several(More)