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To move closer to understanding the mechanistic underpinnings of sex differences in human longevity, we studied pet dogs to determine whether lifetime duration of ovary exposure was associated with exceptional longevity. This hypothesis was tested by collecting and analyzing lifetime medical histories, age at death, and cause of death for a cohort of canine(More)
The pyrimidine deoxyribonucleoside kinase (dPK) genes from five wild-type and four acyclovir-resistant varicella-zoster virus (VZV) strains were studied. One of the acyclovir-resistant strains was isolated from a patient receiving chronic acyclovir therapy. Acyclovir-resistant strains expressed the 1.8 kb VZV dPK transcript but lacked dPK activity. To(More)
Prostate cancer is the product of dysregulated homeostasis within the aging prostate. Supplementation with selenium in the form of selenized yeast (Se-yeast) significantly reduced prostate cancer incidence in the Nutritional Prevention of Cancer Trial. Conversely, the Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed no such cancer-protective(More)
To better understand the potential trade-off between female reproductive investment and longevity in an emerging model of human healthspan, we studied pet dogs to determine whether intensity of reproduction (total number of offspring) encumbered the likelihood of exceptional longevity. This hypothesis was tested by collecting and analyzing lifetime medical(More)
Creative excellence in interdisciplinary research, education, and communication demands stamina and openmindedness. Stamina requires renewal, yet few opportunities for self-renewal are built into most systems. And as experts, our openmindedness is often stifled by our own sense of finishedness. This paper sketches out a strategy for sustained renewal and(More)
Our goal is to call teachers' attention to the need for self-renewal, challenging them to consider it a necessary approach to innovating interdisciplinary education. Our prescription for sustained self-renewal: Each teacher assembles a gallery of intellectual heroes — gifted and articulate thinkers — to serve as their own lifelong teachers. In this paper,(More)
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