Learn More
Optimisation problems often comprise a large set of objectives, and visualising the set of solutions to a problem can help with understanding them, assisting a decision maker. If the set of objectives is larger than three, visualising solutions to the problem is a difficult task. Techniques for visualising high-dimensional data are often difficult to(More)
Interpreting individuals described by a set of criteria can be a difficult task when the number of criteria is large. Such individuals can be ranked, for instance in terms of their average rank across criteria as well as by each distinct criterion. We therefore investigate criteria selection methods which aim to preserve the average rank of individuals but(More)
Multi-objective optimisation yields an estimated Pareto front of mutually non-dominating solutions, but with more than three objectives understanding the relationships between solutions is challenging. Natural solutions to use as <i>landmarks</i> are those lying near to the edges of the mutually non-dominating set. We propose four definitions of <i>edge(More)
OBJECTIVE To investigate whether antidrug antibodies and/or drug non-trough levels predict the long-term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors influencing antidrug antibody and drug levels to optimize future treatment decisions. METHODS A total of 331(More)
Serum and glucocorticoid-inducible kinase 1 (SGK1) is a protein kinase that contributes to the hormonal control of renal Na(+) retention by regulating the abundance of epithelial Na(+) channels (ENaC) at the apical surface of the principal cells of the cortical collecting duct (CCD). Although glucocorticoids and insulin stimulate Na(+) transport by(More)