David J. Spencer

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OBJECTIVE To confirm the prevalence of depression in a sample of rheumatoid arthritis (RA) patients; to identify the most significant predictors of depression in RA and to explore patients attitudes to medication in relation to depression. METHODS A cross-sectional survey was used to collect data from 134 RA patients (77% female, 23% male). Participants(More)
IMPORTANCE Epileptic activity associated with Alzheimer disease (AD) deserves increased attention because it has a harmful impact on these patients, can easily go unrecognized and untreated, and may reflect pathogenic processes that also contribute to other aspects of the illness. We report key features of AD-related seizures and epileptiform activity that(More)
Propranolol 40 mg was compared with a matched placebo tablet in its effect on the performance of anxious and non-anxious human volunteers. Subjects were required to give a brief speech, which was video-taped and later rated by trained observers for signs of anxiety; propranolol clearly reduced rated anxiety in the non-verbal behaviour of anxious subjects,(More)
OBJECTIVE The aim of this study was to evaluate the "real world" effects of the monoclonal antibody omalizumab (OMB) when used to treat severe persistent allergic asthma in UK clinical practice. METHODS A 10-center retrospective observational study was carried out to compare oral corticosteroid (OCS) use and exacerbation frequency in 12 months pre- versus(More)
Growth and form traits data were obtained from eight provenance trials of radiata pine (Pinus radiata D. Don) planted across the radiata pine plantation estate in southeast Australia. The genetic pool included 466 open-pollinated families collected from Año Nuevo, Monterey and Cambria provenances on the Californian mainland coast in the USA and from(More)
135 Failure to thrive has been described in association with chronic intussusception in one previous report.' The authors described three children, aged 10 months to 2-5 years, with clinical histories of seven to 18 weeks' duration. Weight loss and emaciation were described together with abdominal pain and vomiting. Vomiting was a late symptom in our case,(More)
Although no politician will commit career suicide by admitting it, rationing of healthcare is inevitable, whatever the healthcare system, recession or no recession. Medicines, particularly biologicals, modern surgery and intensive care are pushing back the boundaries of what can be done to salvage seemingly hopeless situations, to give but three examples.(More)
(1994): Optimum age for selection in Pinus radiata using basal area under bark for age:age correlations. Silvae Genet. (1996): Results from genetic tests of selected parents of Douglas-fir (Pseudotsuga menziesii [MIRB.] FRANCO) in an applied tree improvement program.): Age-related trends in genetic parameters for jack pine and their implications for early(More)