David J. Spencer

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OBJECTIVE To confirm the prevalence of depression in a sample of rheumatoid arthritis (RA) patients; to identify the most significant predictors of depression in RA and to explore patients attitudes to medication in relation to depression. METHODS A cross-sectional survey was used to collect data from 134 RA patients (77% female, 23% male). Participants(More)
IMPORTANCE Epileptic activity associated with Alzheimer disease (AD) deserves increased attention because it has a harmful impact on these patients, can easily go unrecognized and untreated, and may reflect pathogenic processes that also contribute to other aspects of the illness. We report key features of AD-related seizures and epileptiform activity that(More)
OBJECTIVE The aim of this study was to evaluate the "real world" effects of the monoclonal antibody omalizumab (OMB) when used to treat severe persistent allergic asthma in UK clinical practice. METHODS A 10-center retrospective observational study was carried out to compare oral corticosteroid (OCS) use and exacerbation frequency in 12 months pre- versus(More)
Growth and form traits data were obtained from eight provenance trials of radiata pine (Pinus radiata D. Don) planted across the radiata pine plantation estate in southeast Australia. The genetic pool included 466 open-pollinated families collected from Año Nuevo, Monterey and Cambria provenances on the Californian mainland coast in the USA and from(More)
(1994): Optimum age for selection in Pinus radiata using basal area under bark for age:age correlations. Silvae Genet. (1996): Results from genetic tests of selected parents of Douglas-fir (Pseudotsuga menziesii [MIRB.] FRANCO) in an applied tree improvement program.): Age-related trends in genetic parameters for jack pine and their implications for early(More)
PURPOSE To audit outcomes after introducing frameless stereotactic radiosurgery (SRS) for brain metastases, including co-interventions: neurosurgery, systemic therapy, and whole brain radiotherapy (WBRT). We report median overall survival (MS), local failure, and distant brain failure. We hypothesized patients treated with SRS would have clinically(More)
Some studies suggest that cognitive function is impaired in rheumatoid arthritis patients. One possible influence may be commonly used rheumatoid arthritis treatment, methotrexate. This study examined cognitive function in long-term methotrexate users with rheumatoid arthritis and, using a 24-hour pre- and post-methotrexate dose administration, investigated(More)
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