David J. Pulford

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on the general time reversible model under 1,000 bootstrap iterations , and sequence divergence was determined to calculate the p-distances between sequences. Phylogenetic inference of the sequence data demonstrated 95% nucleotide sequence similarity between the virus from this outbreak and the 14F YFV strain isolated in Angola in 1971 (Figure). PCR and(More)
The ease with which genotyping technologies generate tremendous amounts of data on research participants has been well chronicled, a feat that continues to become both faster and cheaper to perform. In parallel to these advances come additional ethical considerations and debates, one of which centers on providing individual research results and incidental(More)
The collection of viable DNA samples is an essential element of any genetics research programme. Biological samples for DNA purification are now routinely collected in many studies with a variety of sampling methods available. Initial observation in this study suggested a reduced genotyping success rate of some saliva derived DNA samples when compared to(More)
BACKGROUND The focus on translational research in clinical trials has the potential to generate clinically relevant genetic data that could have importance to patients. This raises challenging questions about communicating relevant genetic research results to individual patients. METHODS An exploratory pharmacogenetic analysis was conducted in the(More)
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