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Taxol and other antimitotic agents are frontline chemotherapy agents but the mechanisms responsible for patient benefit remain unclear. Following a genome-wide siRNA screen, we identified the… (More)
Aneuploidy is a common feature of cancer, with human solid tumour cells typically harbouring abnormal chromosome complements. The aneuploidy observed in cancer is often caused by a chromosome… (More)
Samarium(II) iodide (SmI(2)) is one of the most important reducing agents in organic synthesis. Synthetic chemistry promoted by SmI(2) depends on the efficient and reliable preparation of the… (More)
The first enantiospecific total synthesis of the antibacterial natural product (+)-pleuromutilin has been achieved. The approach includes the synthesis of a non-racemic cyclisation substrate from… (More)
Chapter 1: Introduction Chapter 2: The reagent and the effect of additives Chapter 3: Mechanisms of SmI2-mediated reactions - the basics Chapter 4: Functional group transformations using SmI2 Chapter… (More)
Gamma,delta-unsaturated ketones undergo two very different stereoselective cyclization reactions mediated by samarium(II) iodide depending upon the alcohol cosolvent used in the reaction. Switching… (More)
This review focuses on the use of sulfide, sulfoxide, sulfone, selenide and selenoxide linkers in solid-phase and fluorous-phase synthesis.
A review, cyclization reactions in natural product synthesis of 4-9 membered and larger rings were discussed. [on SciFinder (R)]