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While it is well known that serious illness and inflammation reduce male fertility, the mechanisms involved are poorly understood. In adult male rats, a single injection of lipopolysaccharide at doses that induced either mild or severe inflammation, caused a biphasic decline in Leydig cell testosterone production and gonadotropin responsiveness. In the high(More)
As privacy issues have gained social salience, entrepreneurs have begun to offer privacy enhancing technologies (PETs) and the U.S. has begun to enact privacy legislation. But"privacy"is an ambiguous notion. In the liberal tradition, it is an individualistic value protecting citizens from intrusion into a realm of autonomy. A feminist critique suggests that(More)
alpha 2-Macroglobulin (alpha 2-M), a major serum glycoprotein, has been implicated as a low-affinity binding protein for inhibin and activin. In serum, alpha 2-M exists as two major species, a native form that is abundant and stable, and a transformed ('fast') species that is rapidly cleared from the circulation via alpha 2-M receptors. In this study(More)
Activin A is a member of the transforming growth factor-beta superfamily and has been demonstrated to be elevated during inflammation and to have neuroprotective properties following neural insults. In this study, we examined whether traumatic brain injury (TBI) induced a response in activin A or in the concentrations of its binding protein, follistatin.(More)
We studied the impact of endotoxemia on cerebral blood flow (CBF), cerebral vascular resistance (CVR), and cerebral oxygen transport (O(2) transport) in fetal sheep. We hypothesized that endotoxemia impairs CBF regulation and O(2) transport, exposing the brain to hypoxic-ischemic injury. Responses to lipopolysaccharide (LPS; 1 microg/kg iv on 3 consecutive(More)
The regulation of reproductive processes involves a complex network of communication systems between the brain, endocrine organs, the gonads and other reproductive tissues. Classically, our understanding has focused on the role of endocrine hormones, but more recently interest has also dwelt on the paracrine and autocrine regulation of these cell systems.(More)
We describe the semidefinite analog of the vector packing problem, and show that the semidefinite programming relaxations for Maxcut [10] and graph coloring [16] are in this class of problems. We extend a method of Bienstock and Iyengar [4] which was based on ideas from Nesterov [24] to design an algorithm for computing-approximate solutions for this class(More)