David J. Panther

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The cellular interactions and pathways of engineered submicro- and nano-scale particles dictate the cellular response and ultimately determine the level of toxicity or biocompatibility of the particles. Positive surface charge can increase particle internalization, and in some cases can also increase particle toxicity, but the underlying mechanisms are(More)
The growing commerce in micro- and nanotechnology is expected to increase human exposure to submicrometer and nanoscale particles, including certain forms of amorphous silica. When inhaled, these particles are likely to reach the alveoli, where alveolar type II epithelial cells that are distinguished by apical microvilli are found. These cells play critical(More)
tiple invasive, well-differentiated SCCs. These SCCs exemplify the occurrence of epithelial atypia in an area of a chronic nonhealing wound. The unusual clinical scenario presented a therapeutic challenge. Traditional treatment options including surgical, destructive, radiotherapeutic, and photodynamic therapies were not feasible because of the nature and(More)
Atopic dermatitis is a form of dermatitis commonly seen in children and adults. Its pathophysiology is complex and is centered on the barrier function of the epidermis. An important aspect of the skin's barrier is pH, which in turn affects a number of parameters such as the skin flora, protease function, and mediators of inflammation and pruritus. Normal pH(More)
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