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Using a rhabdomyosarcoma patient-derived xenograft to examine precision medicine approaches and model acquired resistance.

• David J Monsma, David M. Cherba, +13 authors Noel R. Monks
• Pediatric blood & cancer
• 2014

BACKGROUND Precision (Personalized) medicine has the potential to revolutionize patient health care especially for many cancers where the fundamental disease etiology remains either elusive or has no… (More)

Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide

• Wendi V. Rodrigueza, Michael J. Woolliscroft, +22 authors Ayad Al-Katib
• Cancer Chemotherapy and Pharmacology
• 2014

PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to a region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of… (More)

Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue

• David J Monsma, Noel R. Monks, +13 authors Craig Paul Webb
• Journal of Translational Medicine
• 2012

There is resurgence within drug and biomarker development communities for the use of primary tumorgraft models as improved predictors of patient tumor response to novel therapeutic strategies.… (More)

Discovery of cancer biomarkers through the use of mouse models.

• Rork Kuick, David E. Misek, +6 authors Samir M Hanash
• Cancer letters
• 2007

Although our understanding of the molecular pathogenesis of common types of cancer has improved considerably, the development of effective strategies for cancer diagnosis and treatment have lagged… (More)

Melanoma patient derived xenografts acquire distinct Vemurafenib resistance mechanisms.

• David J Monsma, David M. Cherba, +11 authors Noel R. Monks
• American journal of cancer research
• 2015

Variable clinical responses, tumor heterogeneity, and drug resistance reduce long-term survival outcomes for metastatic melanoma patients. To guide and accelerate drug development, we characterized… (More)

Establishment of genetically diverse patient-derived xenografts of colorectal cancer.

• Danielle M. Burgenske, David J Monsma, +9 authors Jeffrey P MacKeigan
• American journal of cancer research
• 2014

Preclinical compounds tested in animal models often show limited efficacy when transitioned into human clinical trials. As a result, many patients are stratified into treatment regimens that have… (More)

In vivo safety and antitumor efficacy of bifunctional small hairpin RNAs specific for the human Stathmin 1 oncoprotein.

• Anagha P. Phadke, Chris Jay, +18 authors Alex Tong
• DNA and cell biology
• 2011

Bifunctional small hairpin RNAs (bi-shRNAs) are functional miRNA/siRNA composites that are optimized for posttranscriptional gene silencing through concurrent mRNA cleavage-dependent and -independent… (More)

Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation.

• Chad J Creighton, Jennifer L. Bromberg-White, +8 authors Samir M Hanash
• Molecular cancer research : MCR
• 2005

Tumor cell lines are relied on extensively for cancer investigations, yet cultured cells in an in vitro environment differ considerably in behavior compared with those of the same cancer cells that… (More)

Anoikis-resistant subpopulations of human osteosarcoma display significant chemoresistance and are sensitive to targeted epigenetic therapies predicted by expression profiling

• Jessica Foley, Donald J Scholten II, +7 authors Matthew Richard Steensma
• Journal of Translational Medicine
• 2015

Osteosarcoma (OS) is the most common type of solid bone cancer, with latent metastasis being a typical mode of disease progression and a major contributor to poor prognosis. For this to occur, cells… (More)

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