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Hippocampally-dependent trace eyeblink conditioning has been shown to be affected by aging. Aging animals take more trials to acquire the association and are more likely to be unable to learn the task. Hippocampal neurons show decreased post-burst afterhyperpolarizations (AHPs) and less accomodation after conditioning, in a time-dependent fashion which may(More)
SUMMARY Epilepsy is among the most common neurologic disorders, yet it is estimated that about one third of patients do not respond favorably to currently available drug treatments and up to 50% experience major side effects of these treatments. Although surgical resection of seizure foci can provide reduction or cessation of seizure incidents, a(More)
Epilepsy is a relatively common disease, afflicting 1%-2% of the population, yet many epileptic patients are not sufficiently helped by current pharmacological therapies. Recent reports have suggested that chaos control techniques may be useful for electrically manipulating epileptiform bursting behavior in vitro and could possibly lead to an alternative(More)
PURPOSE A responsive electrical brain stimulation system using control feedback was investigated for the treatment of seizures. METHODS A proportional feedback stimulation system was designed. Penicillin-induced episodic seizures were created in rat primary motor cortex. Both intracranial (proximal to seizure focus) and extracranial EEGs were monitored.(More)
Transcranial magnetic stimulation (TMS) is a noninvasive technique that can alter brain activation by inducing electrical current in neurons using dynamic magnetic fields. Because of its painless nature, clinical usage has expanded to diagnostic purposes and therapeutic treatments. However, several issues and challenges still exist for TMS. A very limited(More)
Neuronal populations in the brain achieve levels of synchronous electrophysiological activity during both normal brain function and pathological states such as epileptic seizures. Understanding how the dynamics of neuronal oscillators in the brain evolve from normal to diseased states is a critical component toward decoding such complex behaviors. In this(More)
Experimental reports have appeared which challenge the dogma that epileptic seizures arise as a consequence of neuronal hypersynchronization. We sought to explore what mechanisms that desynchronize neuronal firing could induce epileptic seizures. A computer model of connections in a mammalian hippocampal slice preparation was constructed including two(More)
OBJECTIVE Improved visualization of intraaneurysmal thrombi can contribute to understanding their impact on clinical courses and treatments. Digital subtraction angiography (DSA) demonstrates the hemodynamic portion of aneurysm domes and vasculature structures and has been considered by many to be the principal technique used for aneurysm diagnosis. An(More)