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INTRODUCTION Data on quality of life beyond 2 years after intensive care discharge are limited and we aimed to explore this area further. Our objective was to quantify quality of life and health utilities in the 5 years after intensive care discharge. METHODS A prospective longitudinal cohort study in a University Hospital in the UK. Quality of life was(More)
Although serial peak expiratory flow (PEF) measurements are often used to assess the variability of airflow obstruction, the range of values to be expected in the general population has never been defined, nor is there any consensus as to how PEF variability should be expressed. We have compared PEF recordings made by 121 subjects selected at random from(More)
Pelvic floor muscle (PFM) training has received Level-A evidence rating in the treatment of stress urinary incontinence (SUI) in women, based on meta-analysis of numerous randomized control trials (RCTs) and is recommended in many published guidelines. However, the actual regimen of PFM training used varies widely in these RCTs. Hence, to date, the optimal(More)
STUDY OBJECTIVES The South Asian population is at increased risk of cardiovascular disease. We compared the prevalence and severity of obstructive sleep apnea (OSA) in South Asians and white Europeans with severe obesity. METHODS Data from consecutive patients attending a specialist weight management service were analyzed. Self-reported age, gender, and(More)
OBJECTIVE To identify factors associated with intention to attend a hypothetical eye health test and provide an evidence base for developing an intervention to maximise attendance, for use in studies evaluating glaucoma screening programmes. DESIGN Theory-based cross-sectional survey, based on an extended Theory of Planned Behaviour (TPB) and the Common(More)
INTRODUCTION We conducted a systematic review of evidence on the effectiveness of imatinib at escalated doses of 600 mg/day or 800 mg/day for treatment of adults with unresectable or metastatic gastrointestinal stromal tumours (GIST), following progression on imatinib at the 400 mg/day dose, compared with sunitinib and/or 'best supportive care'. METHODS(More)
BACKGROUND To develop patient-reported outcome instruments, statistical techniques (e.g., principal components analysis; PCA) are used to examine correlations among items and identify interrelated item subsets (empirical factors). However, interpretation and labelling of empirical factors is a subjective process, lacking precision or conceptual basis. We(More)
AdvAntAges of rAnkIng treAtment optIons Conservative treatment options for women with stress urinary incontinence include lifestyle changes, pelvic floor muscle training, behavioural techniques, electrical stimulation and drugs, and combinations of these individual therapies. It would be very helpful to patients, primary care clinicians, and commissioners(More)
OBJECTIVES To investigate whether intergroup contact in addition to education is more effective than education alone in reducing stigma of mental illness in adolescents. DESIGN A pragmatic cluster randomised controlled trial compared education alone with education plus contact. Blocking was used to randomly stratify classes within schools to condition.(More)
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