David J Houlihan

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OBJECTIVE To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine. CASE SUMMARY A 47-year-old white man receiving combined mirtazapine and venlafaxine therapy for major depressive disorder developed agitation, confusion, severe shivering, diaphoresis, myoclonus,(More)
Forty-seven schizophrenic patients and 36 normal controls, matched for smoking history, were administered the University of Pennsylvania Smell Identification Test (UPSIT) and the Picture Identification Test (PIT). Amongst subjects successfully completing the PIT, non-smoking schizophrenic patients had significantly lower UPSIT scores than non-smoking(More)
Altered serotonin transmission has been associated with behavioral complications of degenerative dementia. This study examined whether trazodone, a serotonergic antidepressant, may be useful in treating behavioral syndromes associated with dementia. Twenty-two dementia patients with behavioral problems were treated with trazodone (mean daily dose 172 ± 107(More)
The objective of this paper is to describe three cases of combat-related posttraumatic stress disorder (PTSD), largely refractory to standard medication treatment who responded well to psychostimulant treatment. Symptoms of PTSD potentially result from chronic, stress-induced dopaminergic dysfunction in the prefrontal cortex/basal ganglia system.(More)
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