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GM crops have great potential to improve food quality, increase harvest yields and decrease dependency on certain chemical pesticides. Before entering the market their safety needs to be scrutinized. This includes a detailed analysis of allergenic risks, as the safety of allergic consumers has high priority. However, not all tests currently being applied to(More)
In neonatal rodents, the-cell mass undergoes a phase of remodeling that includes a wave of apoptosis. Using both mathematical modeling and histochemical detection methods, we have demonstrated that-cell apo-ptosis is significantly increased in neonates as compared with adult rats, peaking at ~2 weeks of age. Other tissues, including the kidney and nervous(More)
—This paper presents a Web 2.0 virtual observatory framework applied in an environmental watershed research context, where users not only can access existing sensor data such as the USGS (United States Geological Survey) rain gage data in near real-time, but also can create and share virtual sensors and trigger their associated workflows on-the-fly.(More)
This paper presents a method of optimal coordination of load shedding, capacitor switching and tap changer operation using a dynamic system model in order to preserve long-term voltage stability. The method is based on model predictive control and tree search. A model of the controlled system, including the network and load dynamics, is used to predict the(More)
OBJECTIVE Recently we have shown that calpain-1 activation contributes to cardiomyocyte apoptosis induced by hyperglycemia. This study was undertaken to investigate whether targeted disruption of calpain would reduce myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. RESEARCH DESIGN AND METHODS Diabetes in mice was induced by(More)
In Type 1 diabetes, the insulin-producing β-cells within the pancreatic islets of Langerhans are destroyed. We showed previously that immunotherapy with Bacillus Calmette-Guerin (BCG) or complete Freund’s adjuvant (CFA) of non-obese diabetic (NOD) mice can prevent disease process and pancreatic β-cell loss. This was associated with increased islet(More)
Beta cells are partially replaced in neonatal rodents after deletion with streptozotocin (STZ). Exposure of pregnant rats to a low protein (LP) diet impairs endocrine pancreas development in the offspring, leading to glucose intolerance in adulthood. Our objective was to determine whether protein restriction has a similar effect on the offspring in mice,(More)
This study of children (ages 7 through 12) wishes to determine (a) whether variation in frontal lobe brain chemistry, determined from proton magnetic resonance spectroscopy (1H-MRS), is related to performance on a working memory task in children, and (b) whether developmental instability (DI; the imprecise expression of the genetic plan for development due(More)
Recent advances in sensor technology are facilitating the deployment of sensors into the environment that can produce measurements at high spatial and/or temporal resolutions. Not only can these data be used to better characterize systems for improved modeling, but they can also be used to produce better understandings of the mechanisms of environmental(More)
The role of primary prevention of allergic diseases has been a matter of debate for the last 40 years. In order to shed some light on this issue, a group of experts of the Section of Pediatrics EAACI reviewed critically the existing literature on the subject. An analysis of published peer-reviewed observational and interventional studies was performed(More)