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  • Michael H. Court, Soundarajan Krishnaswamy, +4 authors David J Greenblatt
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2003 (First Publication: 1 September 2003)
  • UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in the glucuronidation of a wide array of clinically important drugs and endogenous compounds in humans. The aim of this study was to identify anContinue Reading
  • Kiran C. Patki, Lisa L. von Moltke, David J Greenblatt
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2003 (First Publication: 1 July 2003)
  • Midazolam, triazolam (TRZ), testosterone, and nifedipine have all been widely used as probes for in vitro metabolism of CYP3A. We used these four substrates to assess the contributions of CYP3A4 andContinue Reading
  • Shirley M Tsunoda, Rebeca Vélez, Lisa L von Moltke, David J Greenblatt
  • Medicine
  • Clinical pharmacology and therapeutics
  • 1999 (First Publication: 1 November 1999)
  • BACKGROUND The cytochrome P450 3A (CYP3A) isoforms are responsible for the metabolism of a majority of therapeutic compounds, and they are abundant in the intestine and liver. CYP3A activity isContinue Reading
  • Leah M. Hesse, Karthik Venkatakrishnan, +4 authors David J Greenblatt
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2000 (First Publication: 1 October 2000)
  • The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing heterologously expressed human cytochromes P450 (CYP). The meanContinue Reading
  • Michael D. Perloff, Lisa L. von Moltke, Michael H. Court, Tsutomu Kotegawa, Richard I. Shader, David J Greenblatt
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2000 (First Publication: 1 February 2000)
  • Midazolam (MDZ) and triazolam (TRZ) hydroxylation, reactions considered to be cytochrome P-4503A (CYP3A)-mediated in humans, were examined in mouse and human liver microsomes. In both species, alpha-Continue Reading