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BACKGROUND Remission and radiographic non-progression are goals in the treatment of early rheumatoid arthritis. The aim of the combination of methotrexate and etanercept in active early rheumatoid arthritis (COMET) trial is to compare remission and radiographic non-progression in patients treated with methotrexate monotherapy or with methotrexate plus(More)
This paper describes concepts and techniques to measure the flexibility of a transportation system to accommodate changing demands and traffic patterns. Flexibility is increasingly desired as a characteristic of transport systems, particularly in light of changes in supply chains and traffic patterns, and the concern for the vulnerability of the system to(More)
PURPOSE Statistical parametric mapping (SPM) is an image-analysis tool that assesses the statistical significance of cerebral blood flow (CBF) changes on a voxel-by-voxel basis, thereby removing the subjectivity inherent in conventional region-of-interest (ROI) analysis. Our platform of single-photon emission computed tomography (SPECT) ictal-interictal(More)
OBJECTIVES To evaluate the efficacy and safety of intravenous ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, active rheumatoid arthritis (RA) patients despite methotrexate treatment. METHODS In this double-blind, placebo-controlled, phase III study, active RA patients on stable methotrexate were randomly assigned to one(More)
  • Yi-Rong Zhu, Jin Kim, David J Chang, Ya-Chi Tsao, Huafang Cui, Peter M Hahn
  • 2007
2007 iii DEDICATION To My Parents iv ACKNOWLEDGEMENTS I am deeply indebted to many individuals who have helped me greatly during preparation of this dissertation. I particularly thank and recognize the guidance and patience of my advisor, Professor Peter M. Hahn. Without his instruction, this work could not have been possible. I appreciate the very much(More)
BACKGROUND Lamprey, basal vertebrate, is an important model system for understanding early events in vertebrate evolution. Lamprey contains orthologs of the estrogen receptor [ER], progesterone receptor and corticoid receptor. A perplexing property of lamprey is that 15alpha-hydroxy-steroids are active steroids. For example, 15alpha-hydroxy-estradiol(More)
Sea lamprey, a basal vertebrate, contains a progesterone receptor [PR]. An unusual property of lamprey is that gonadotropin-releasing hormone induces synthesis of 15α-hydroxy-progesterone [15α-OH-P] instead of progesterone. There also is indirect evidence for 7α-OH-P in lamprey serum. To determine if there is a structural basis for the binding of 7α-OH-P(More)
Background: Lamprey, basal vertebrate, is an important model system for understanding early events in vertebrate evolution. Lamprey contains orthologs of the estrogen receptor [ER], progesterone receptor and corticoid receptor. A perplexing property of lamprey is that 15a-hydroxy-steroids are active steroids. For example, 15a-hydroxy-estradiol [15a-OH-E2](More)
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