David J. Apple

Learn More
A complication of extracapsular cataract extraction with or without posterior chamber intraocular lens (PC-IOL) implantation is posterior capsule opacification. This condition is usually secondary to a proliferation and migration of residual lens epithelial cells. Opacification may be reduced by atraumatic surgery and thorough cortical clean-up. Clinical,(More)
Although anomalies affecting the optic nerve head are usually clinically innocuous, they can sometimes cause significant symptoms and lead to visual loss. It is important to be able to recognize even the relatively benign lesions in order to differentiate them from other more threatening lesions or disease processes which they may clinically resemble. An(More)
OBJECTIVE To report clinical, pathological and histochemical features of 5 Hydroview intraocular lenses (IOLs) explanted from five patients who had visual disturbances caused by postoperative deposits on the lens surfaces. DESIGN Noncomparative small case series with clinicopathologic and histochemical correlations. PARTICIPANTS Five hydrophilic IOLs(More)
AbstractPurpose To report and compare clinical and pathological features of hydrophilic acrylic intraocular lenses (IOLs) of three major designs, explanted from patients who had visual disturbances caused by opacification of the lens optic.Methods Eighty-seven hydrophilic acrylic IOLs (25 HydroviewTM, 54 SC60B-OUV, and 8 Aqua-SenseTM lenses) were explanted(More)
PURPOSE To evaluate the ability and safety of a hydrophilic acrylic intraocular lens (IOL) as a drug-delivery system for commercially available gatifloxacin and moxifloxacin. SETTING David J. Apple, MD, Laboratories for Ophthalmic Research, John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah,(More)
PURPOSE The authors analyzed incidence and types of complications seen after implantation of silicone posterior chamber intraocular lenses (PC IOLs). These data were compared with those obtained in previous studies with standard polymethylmethacrylate IOLs. METHODS Data from the laboratory database were collected on 100 explanted silicone IOLs submitted(More)
OBJECTIVE To compare the degree of anterior capsule opacification (ACO) in human eyes obtained post-mortem containing various rigid and foldable posterior chamber intraocular lens (PC-IOL) designs. DESIGN Comparative autopsy tissue study with clinicopathologic correlations. MATERIALS Four hundred sixty human globes containing the following PC-IOL styles(More)
PURPOSE To evaluate anterior capsule staining using 3 dyes to perform continuous curvilinear capsulorhexis (CCC) in postmortem human eyes with advanced/white cataract. SETTING Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA. METHODS In experimental(More)
The evolution of various plastic materials used in the manufacture of intraocular lenses is reviewed, with special reference to the problem of biocompatibility of lens haptic materials. To date, polypropylene has been found and continues to be a highly effective, relatively inert material, providing good surgical results. However, the present study and(More)