David J. Altman

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There is substantial evidence that dendritic cells (DC) residing within epithelial surfaces (e.g., Langerhans cells) are the initial cells infected with HIV after mucosal exposure to virus. To study DC-HIV interactions in detail, we propagated Langerhans cell-like DC from cord blood CD34(+) cells and from adult blood plastic-adherent PBMC in the presence of(More)
Interleukin (IL)-15 is a recently described cytokine that shares many functional activities with IL-2; however, unlike IL-2, IL-15 is produced by monocytes/macrophages, and not by lymphocytes. In this report, we assessed IL-15 mRNA expression by freshly isolated human epidermal cells, as well as by negatively selected keratinocytes and positively selected(More)
This report describes a murine amniotic fluid (MAF) immunosuppressive factor that has properties similar to transforming growth factor 0 (TGF-R) . The MAP factor exhibits TGF-0-like activity in stimulating soft agar colony formation by AKR-2B cells and inhibiting thymidine uptake by Mv1Lu cells. We demonstrate that both the immunosuppressive and TGF-#-like(More)
A healthy 5-year-old boy came to our clinic for a generalized asymptomatic eruption that had been present for 3 months. He had been unsuccessfully treated with topical steroids and immunomodulators. On physical examination, we found numerous tiny flesh-colored flattopped papules on the anterior and posterior trunk, extremities, and face (Figure 1 and Figure(More)
This report describes a murine amniotic fluid (MAF) immunosuppressive factor that has properties similar to transforming growth factor beta (TGF-beta). The MAF factor exhibits TGF-beta-like activity in stimulating soft agar colony formation by AKR-2B cells and inhibiting thymidine uptake by Mv1Lu cells. We demonstrate that both the immunosuppressive and(More)
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