David I Tovey

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in its infancy. The term “evidence-based medicine” had recently been coined at McMaster University, the Institute of Medicine had published an influential report on developing clinical guidelines, and about 500 systematic reviews were indexed in MEDLINE annually. Against this backdrop, 77 people from 11 countries attended the first Cochrane Colloquium in(More)
Editors from a number of medical journals lay out principles for journals considering publication of Comparative Effectiveness Research (CER). In order to encourage dissemination of this editorial, this article is freely available in PLoS Medicine and will be also published in Medical Decision Making, Croatian Medical Journal, The Cochrane Library, Trials,(More)
Evidence evolves as new research becomes available, and thus systematic reviews should be kept up to date to maintain their relevance and validity. However, the decision to update a systematic review should be made carefully because updating is potentially resource intensive, and updating too soon could introduce bias. In contrast, if reviews are not(More)
Ben Goldacre research fellow in epidemiology, London School of Hygiene and Tropical Medicine, Fiona Godlee editor in chief, The BMJ, Carl Heneghan director, Centre for Evidence based Medicine, Oxford, David Tovey editor in chief, Cochrane Library, Richard Lehman general practitioner, Oxfordshire, Iain Chalmers coordinator, James Lind Initiative, Virginia(More)
The Cochrane Collaboration is a global network whose aim is to improve health-care decision making through systematic reviews of the effects of health-care interventions. Cochrane systematic reviews are published in the Cochrane Database of Systematic Reviews within The Cochrane Library ( http://www.thecochranelibrary.com), and regularly updated as new(More)
OBJECTIVE Although protocol registration for systematic reviews is still not mandatory, reviewers should be strongly encouraged to register the protocol to identify the methodological approach, including all outcomes of interest. This will minimize the likelihood of biased decisions in reviews, such as selective outcome reporting. A group of international(More)