Preclinical studies indicate that the cyclin-dependent kinase and protein kinase C inhibitor 7-hydroxystaurosporine (UCN-01) potentiates the cytotoxic effects of fluorouracil (FU). We designed a phase I clinical trial of FU in combination with UCN-01.
PATIENTS AND METHODS
FU was administered as a weekly 24-hour infusion. Doses were escalated in… (More)