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Optical coherence tomography angiography (OCTA) is a noninvasive approach that can visualize blood vessels down to the capillary level. With the advent of high-speed OCT and efficient algorithms, practical OCTA of ocular circulation is now available to ophthalmologists. Clinical investigations that used OCTA have increased exponentially in the past few(More)
PURPOSE To map ganglion cell complex (GCC) thickness with high-speed Fourier-domain optical coherence tomography (FD-OCT) and compute novel macular parameters for glaucoma diagnosis. DESIGN Observational, cross-sectional study. PARTICIPANTS One hundred seventy-eight participants in the Advanced Imaging for Glaucoma Study, divided into 3 groups: 65(More)
Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation(More)
Optic nerve head (ONH) blood flow may be associated with glaucoma development. A reliable method to quantify ONH blood flow could provide insight into the vascular component of glaucoma pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), we developed a new 3D angiography algorithm called split-spectrum amplitude-decorrelation(More)
Analysis of large, complex systems requires simulations of hybrid-system dynamics, i.e., dynamics which are best described by a combination of continuous-time and discrete-event models, and their interactions. To serve as valuable research tools, such simulations need also be computationally efficient, readily modifiable, and open to a wide range of(More)
Doppler OCT provides depth-resolved information on flow in biological tissues. In this article, we demonstrate ultrahigh speed swept source/Fourier domain OCT for visualization and quantitative assessment of retinal blood flow. Using swept laser technology, the system operated in the 1050-nm wavelength range at a high axial scan rate of 200 kHz. The rapid(More)
Purpose—To identify the best combination of Stratus optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness parameters for the detection of glaucoma. Design—Observational cross-sectional study. Participants—Eighty-nine age-matched normal and perimetric glaucoma participants enrolled in the Advanced Imaging for Glaucoma Study.(More)
PURPOSE To evaluate the reproducibility of anterior chamber (AC) angle measurements obtained using anterior segment optical coherence tomography (AS-OCT). METHODS Patients with suspected glaucoma and those with glaucoma, ocular hypertension, or anatomically narrow angles were recruited from the glaucoma service at the National University Hospital,(More)
BACKGROUND AND AIMS Studies suggest that stroke patients with thrombus in a major cerebral vessel respond less favorably to intravenous (IV) thrombolysis. The purpose of this study was to test the feasibility of a protocol comparing IV versus intra-arterial (IA) recombinant tissue plasminogen activator (TPA) in an acute ischemic stroke with major vessel(More)
PURPOSE To determine the relationship between retinal nerve fiber layer (RNFL) thickness, optic disc size, and image magnification. METHODS The cohort consisted of 196 normal eyes of 101 participants in the Advanced Imaging for Glaucoma Study (AIGS), a multicenter, prospective, longitudinal study to develop advanced imaging technologies for glaucoma(More)