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BACKGROUND We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. METHODS Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. (More)
BACKGROUND Central blood pressure (BP) and markers of wave reflection (augmentation index; AIx) measured by radial tonometry have prognostic value independent from brachial BP. The measurement of the central waveform is increasingly used during altered hemodynamics, including exercise, but reliability of the test has not been reported under changed loading(More)
Since the successful launch of IKONOS in 1999, a new source of imagery has been available to the civilian spatial-data user. In many parts of the world high resolution satellite imagery from IKONOS, QuickBird and, more recently, ORBVIEW 3, has proved to be a useful data source for the creation of orthorectified images and associated mapping products. One of(More)
OBJECTIVES The aim of this study was to test the effects of treatment with ivabradine on exercise capacity and left ventricular filling in patients with heart failure with preserved ejection fraction (HFpEF). BACKGROUND Because symptoms of HFpEF are typically exertional, optimization of diastolic filling time by controlling heart rate may delay the onset(More)
We recently managed 4 patients with cystic fibrosis who had acquired Burkholderia pseudomallei infection after exposure in a region of endemicity. Person-to-person transmission between 2 siblings may have occurred; otherwise, the evidence suggests that cystic fibrosis may increase the likelihood of infection with this organism, and patients should be warned(More)
Key Points: The microbiome has been implicated in the development of obesity. Conventional therapeutic methods have limited effectiveness for the treatment of obesity and prevention of related complications. Gut microbiome transplantation may represent an alternative and effective therapy for the treatment of obesity. Obesity has reached epidemic(More)
We describe the case of a south Asian man who developed symptomatic intracranial tuberculomas while on therapy for pulmonary tuberculosis. The development or progression of intracranial tuberculomas during the course of appropriate antituberculous therapy has been recognised previously. We review the epidemiology, pathophysiology, diagnosis, and treatment(More)
Interaction of Greenland's marine-terminating glaciers with the ocean has emerged as a key term in the ice-sheet mass balance and a plausible trigger for their recent acceleration. Our knowledge of the dynamics, however, is limited by scarcity of ocean measurements at the glacier/ocean boundary. Here data collected near six marine-terminating glaciers (79(More)
The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients(More)
The national distribution of Fallopia japonica (Japanese Knotweed), Heracleum mantegazzianum (Giant Hogweed) and Impatiens glandulifera (Himalayan Balsam) in bankside habitats is given for 1994-96 in the U.K. and contrasted with the occurrence of large stands of other nuisance plants. The typical habitats of these plants were derived by analysis of flow,(More)